Lipoxygenase
Read More about this categoryShow Less
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products Related to Lipoxygenase(264)
- GC4109512(S)-HpEPECAS: 103239-14-1Purity: >96.00%
12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid.
- GC4109612-oxo Leukotriene B4CAS: 136696-10-1Purity: >90.00%
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.
- GC4110014,15-dehydro Leukotriene B4CAS: 114616-11-4Purity: >97.00%
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.
- GC4110115(S)-HpEPECAS: 125992-60-1Purity: >98.00%
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid.
- GC411055(S)-HpEPECAS: 143292-98-2Purity: >95.00%
5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA.
- GC41107Leukotriene B5CAS: 80445-66-5Purity: >98.00%
Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.
- GC4112212(S)-HpETECAS: 71774-10-2Purity: >98.00%
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.
- GC4112312-epi Leukotriene B4CAS: 83709-73-3Purity: >97.00%
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes.
- GC4112415(S)-HpETECAS: 70981-96-3Purity: >95.00%
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid.
- GC411265(S),12(S)-DiHETECAS: 79056-01-2Purity: >98.00%
5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid.
- GC411275(S),15(S)-DiHETECAS: 82200-87-1Purity: >98.00%
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE.
- GC411285(S),6(R)-11-trans DiHETECAS: 129263-59-8Purity: >95.00%
5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor.
- GC411368(S),15(S)-DiHETECAS: 80234-65-7Purity: >98.00%
8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO.
- GC4114411-trans Leukotriene C4CAS: 74841-69-3Purity: >97.00%
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4.
- GC4114514,15-Leukotriene C4CAS: 75290-60-7Purity: >95.00%
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.
- GC4114711-trans Leukotriene D4CAS: 79768-40-4Purity: >97.00%
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4.
- GC4114814,15-Leukotriene D4CAS: 75290-64-1Purity: >97.00%
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates.
- GC4114911-trans Leukotriene E4CAS: 75715-88-7Purity: >97.00%
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4.
- GC4115014,15-Leukotriene E4CAS: 1000852-57-2Purity: >97.00%
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes.
- GC41189Ricinelaidic AcidCAS: 540-12-5Purity: >98.00%
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes).
- GC4120614(S)-HDHACAS: 119433-37-3Purity: >98.00%
Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer.
- GC4120817(S)-HDHACAS: 92693-03-3Purity: >98.00%
17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.
- GC4120917-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic AcidCAS: 1233715-33-7Purity: >98%
Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils.
- GC41211Anacardic Acid DieneCAS: 103904-74-1Purity: >95.00%
Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC41095 | 12(S)-HpEPE | 103239-14-1 | >96.00% | |
12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid. | ||||
| GC41096 | 12-oxo Leukotriene B4 | 136696-10-1 | >90.00% | |
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. | ||||
| GC41100 | 14,15-dehydro Leukotriene B4 | 114616-11-4 | >97.00% | |
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. | ||||
| GC41101 | 15(S)-HpEPE | 125992-60-1 | >98.00% | |
15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid. | ||||
| GC41105 | 5(S)-HpEPE | 143292-98-2 | >95.00% | |
5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. | ||||
| GC41107 | Leukotriene B5 | 80445-66-5 | >98.00% | |
Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. | ||||
| GC41122 | 12(S)-HpETE | 71774-10-2 | >98.00% | |
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. | ||||
| GC41123 | 12-epi Leukotriene B4 | 83709-73-3 | >97.00% | |
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. | ||||
| GC41124 | 15(S)-HpETE | 70981-96-3 | >95.00% | |
15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. | ||||
| GC41126 | 5(S),12(S)-DiHETE | 79056-01-2 | >98.00% | |
5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid. | ||||
| GC41127 | 5(S),15(S)-DiHETE | 82200-87-1 | >98.00% | |
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. | ||||
| GC41128 | 5(S),6(R)-11-trans DiHETE | 129263-59-8 | >95.00% | |
5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. | ||||
| GC41136 | 8(S),15(S)-DiHETE | 80234-65-7 | >98.00% | |
8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. | ||||
| GC41144 | 11-trans Leukotriene C4 | 74841-69-3 | >97.00% | |
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. | ||||
| GC41145 | 14,15-Leukotriene C4 | 75290-60-7 | >95.00% | |
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. | ||||
| GC41147 | 11-trans Leukotriene D4 | 79768-40-4 | >97.00% | |
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. | ||||
| GC41148 | 14,15-Leukotriene D4 | 75290-64-1 | >97.00% | |
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. | ||||
| GC41149 | 11-trans Leukotriene E4 | 75715-88-7 | >97.00% | |
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. | ||||
| GC41150 | 14,15-Leukotriene E4 | 1000852-57-2 | >97.00% | |
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. | ||||
| GC41189 | Ricinelaidic Acid | 540-12-5 | >98.00% | |
Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). | ||||
| GC41206 | 14(S)-HDHA | 119433-37-3 | >98.00% | |
Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. | ||||
| GC41208 | 17(S)-HDHA | 92693-03-3 | >98.00% | |
17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. | ||||
| GC41209 | 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid | 1233715-33-7 | >98% | |
Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. | ||||
| GC41211 | Anacardic Acid Diene | 103904-74-1 | >95.00% | |
Anacardic acid diene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. | ||||