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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC40449 structure
    GC4044912(S)-HETE MaxSpec® Standard
    CAS: 54397-83-0
    Purity: >98.00%

    12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.

  • GC40451 structure
    GC4045115(S)-HETE
    CAS: 54845-95-3
    Purity: >98.00%

    15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.

  • GC40452 structure
    GC4045215(S)-HETE MaxSpec® Standard
    CAS: 54845-95-3
    Purity: >98.00%

    15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.

  • GC40459 structure
    GC404595(R)-HETE
    CAS: 61641-47-2
    Purity: >98.00%

    5(R)-HETE is a rare lipoxygenase product of arachidonic acid.

  • GC40461 structure
    GC404615(S)-HETE MaxSpec® Standard
    CAS: 70608-72-9
    Purity: >98.00%

    5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide.

  • GC40462 structure
    GC404628(R)-HETE
    CAS: 105500-09-2
    Purity: >98.00%

    8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish.

  • GC40463 structure
    GC404638(S)-HETE
    CAS: 98462-03-4
    Purity: >98.00%

    8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis.

  • GC40542 structure
    GC405429(R)-HODE
    CAS: 10075-11-3
    Purity: >98.00%

    9(R)-HODE is one of several monohydroxylated products of linoleic acid.

  • GC40609 structure
    GC40609Lipoxin A5
    CAS: 110657-98-2
    Purity: >95.00%

    Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes.

  • GC40631 structure
    GC40631Leukotriene B4-3-aminopropylamide
    CAS: 89596-43-0
    Purity: >95.00%

    The effects of leukotriene B4 (LTB4) are mediated by two receptors, BLT1 and BLT2.

  • GC40697 structure
    GC40697DDA
    CAS: 25152-84-5
    Purity: >98.00%

    DDA is a lipid peroxidation product of linolieic acid.

  • GC40784 structure
    GC407845(Z),8(Z),14(Z)-Eicosatrienoic Acid
    CAS: 90105-02-5
    Purity: >98.00%

    5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO).

  • GC40828 structure
    GC40828(±)5-HETE lactone
    CAS: 73279-37-5
    Purity: >98.00%

    (±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE.

  • GC40829 structure
    GC408295(S)-HETE lactone
    CAS: 127708-42-3
    Purity: >98.00%

    5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE.

  • GC40830 structure
    GC408305,6-dehydro Arachidonic Acid
    CAS: 58688-54-3
    Purity: >98.00%

    5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position.

  • GC40839 structure
    GC4083915(S)-HETE methyl ester
    CAS: 70946-44-0
    Purity: >98.00%

    15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway.

  • GC40840 structure
    GC40840Leukotriene A3 methyl ester
    CAS: 83851-38-1
    Purity: >97.00%

    Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes.

  • GC40971 structure
    GC4097110(S),17(S)-DiHDHA
    CAS: 871826-47-0
    Purity: >98.00%

    Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.

  • GC40975 structure
    GC4097517(S)-HpDHA
    CAS: 123673-33-6
    Purity: >98.00%

    17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain.

  • GC40978 structure
    GC409787-epi Maresin 1
    CAS: 1268720-66-6
    Purity: >95.00%

    7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1, which contains a 7(R) hydroxyl group.

  • GC40980 structure
    GC40980Maresin 2
    CAS: 1639809-46-3
    Purity: ≥95.00%

    Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.

  • GC40981 structure
    GC40981Protectin D1
    CAS: 660430-03-5
    Purity: >98.00%

    Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.

  • GC40982 structure
    GC40982Resolvin D5
    CAS: 578008-43-2
    Purity: >95.00%

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

  • GC41044 structure
    GC41044CAY10583
    CAS: 862891-27-8
    Purity: >98.00%

    Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis.