ROS
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ROS is a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. ROS kinase is one of the last two remaining orphan receptor tyrosine kinases. It is thought also that c-ROS gene may have a role in some cardiovascular diseases, and the fact that homozygous male mice targeted against c-ROS gene are healthy but infertile, has inspired researchers to think about ROS inhibition as a method for development of new male contraceptives. The new selective and potent inhibitors for ROS kinase, along with the development of new specific diagnostic methods for the detection of ROS fusion proteins, raises the importance of using these selective inhibitors for targeting ROS mutations as a new method for treatment of cancers harboring such genes.
Products Related to ROS(35)
- GC43268Cinnamtannin B-1CAS: 88082-60-4Purity: >98.00%
Cinnamtannin B-1 is a proanthocyanidin polyphenol originally isolated from cinnamon bark that has antioxidant properties.
- GC60312Purpurin 18CAS: 25465-77-4Purity: >95.00%
Purpurin 18 is a chlorophyll-derived chlorin photosensitizer that absorbs near-infrared light in the 700–850nm range and generates reactive oxygen species (ROS) to disrupt mitochondrial membrane potential and induce apoptosis.
- GC60884GOT1 inhibitor-1CAS: 732973-87-4Purity: >98.00%
GOT1 inhibitor-1 is a small-molecule selective inhibitor of GOT1 (glutamic oxaloacetic transaminase 1) with an IC 50 of 8.2 μM. GOT1 inhibitor-1 has potential application value in cancer therapy.
- GC62351TaletrectinibCAS: 1505515-69-4Purity: >99.50%
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants.
- GC64329Avasopasem manganeseCAS: 435327-40-5Purity: >96.00%
Avasopasem manganese is a selective superoxide dismutase mimetic that rapidly and specifically convert O 2 ·− into hydrogen peroxide (H 2 O 2 ), protecting against IR-induced oral mucositis and lung fibrosis.
- GD20803ROS fluorescent probe DHECAS: 38483-26-0Purity: >98.00%
ROS fluorescent probe DHE is the commonly used fluorescent dyes to measure ROS in cells and tissues at 480nm wavelength excitation and 610nm wavelength emission.
- GD21201Sulfo-SANPAHCAS: 102568-43-4Purity: >99.50%
Sulfo-SANPAH is a water-soluble, heterobifunctional crosslinker; Sulfo-SANPAH contains a primary amine-reactive NHS ester and a photoactivatable nitrophenyl azide group.
- GF10446Keyhole limpet hemocyaninCAS: 9013-72-3Purity: ≥85.00%
Keyhole limpet hemocyanin is a highly immunogenic copper-containing respiratory protein derived from the marine mollusk Megathura crenulata .
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC43268 | Cinnamtannin B-1 | 88082-60-4 | >98.00% | |
Cinnamtannin B-1 is a proanthocyanidin polyphenol originally isolated from cinnamon bark that has antioxidant properties. | ||||
| GC50566 | AA 147 | 393121-74-9 | >99.50% | |
AA 147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. | ||||
| GC60312 | Purpurin 18 | 25465-77-4 | >95.00% | |
Purpurin 18 is a chlorophyll-derived chlorin photosensitizer that absorbs near-infrared light in the 700–850nm range and generates reactive oxygen species (ROS) to disrupt mitochondrial membrane potential and induce apoptosis. | ||||
| GC60884 | GOT1 inhibitor-1 | 732973-87-4 | >98.00% | |
GOT1 inhibitor-1 is a small-molecule selective inhibitor of GOT1 (glutamic oxaloacetic transaminase 1) with an IC 50 of 8.2 μM. GOT1 inhibitor-1 has potential application value in cancer therapy. | ||||
| GC62351 | Taletrectinib | 1505515-69-4 | >99.50% | |
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC50s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants. | ||||
| GC62633 | GGTI-2154 | 251577-10-3 | >98% | |
GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 can be used for the research of cancer. | ||||
| GC64329 | Avasopasem manganese | 435327-40-5 | >96.00% | |
Avasopasem manganese is a selective superoxide dismutase mimetic that rapidly and specifically convert O 2 ·− into hydrogen peroxide (H 2 O 2 ), protecting against IR-induced oral mucositis and lung fibrosis. | ||||
| GD20803 | ROS fluorescent probe DHE | 38483-26-0 | >98.00% | |
ROS fluorescent probe DHE is the commonly used fluorescent dyes to measure ROS in cells and tissues at 480nm wavelength excitation and 610nm wavelength emission. | ||||
| GD21201 | Sulfo-SANPAH | 102568-43-4 | >99.50% | |
Sulfo-SANPAH is a water-soluble, heterobifunctional crosslinker; Sulfo-SANPAH contains a primary amine-reactive NHS ester and a photoactivatable nitrophenyl azide group. | ||||
| GF10446 | Keyhole limpet hemocyanin | 9013-72-3 | ≥85.00% | |
Keyhole limpet hemocyanin is a highly immunogenic copper-containing respiratory protein derived from the marine mollusk Megathura crenulata . | ||||
| GF11023 | Hecubine | 62874-52-6 | >98.00% | |
Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis , with anti-neuroinflammation properties. | ||||