Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Mitophagy

Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Targets for  Mitophagy

Products for  Mitophagy

  1. Cat.No. Product Name Information
  2. GC11720 17-AAG (KOS953) An inhibitor of Hsp90 17-AAG (KOS953)  Chemical Structure
  3. GC10710 3-Methyladenine

    3-Methyladenine is a classic autophagy inhibitor.

    3-Methyladenine  Chemical Structure
  4. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride)  Chemical Structure
  5. GC16267 6-Hydroxydopamine hydrobromide Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. 6-Hydroxydopamine hydrobromide  Chemical Structure
  6. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737  Chemical Structure
  7. GC10518 AICAR

    An activator of AMPK

    AICAR  Chemical Structure
  8. GC10580 AICAR phosphate AMPK activator AICAR phosphate  Chemical Structure
  9. GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor Aspirin (Acetylsalicylic acid)  Chemical Structure
  10. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618  Chemical Structure
  11. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid  Chemical Structure
  12. GC17683 Brefeldin A

    Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.

    Brefeldin A  Chemical Structure
  13. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine  Chemical Structure
  14. GC15083 Celastrol A triterpenoid antioxidant Celastrol  Chemical Structure
  15. GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol (Iodochlorhydroxyquin)  Chemical Structure
  16. GC30360 Cresol (Cresol mixture of isomers) Cresol (Cresol mixture of isomers)  Chemical Structure
  17. GC14787 Curcumin A yellow pigment with diverse biological activities Curcumin  Chemical Structure
  18. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS. Curcumin-d6  Chemical Structure
  19. GC13554 Deferoxamine mesylate

    Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.

    Deferoxamine mesylate  Chemical Structure
  20. GC40775 Dexamethasone

    Dexamethasone, as one member of the glucocorticoid family, can protect against arthritis-related changes in cartilage structure and function, including matrix loss, inflammation and cartilage viability.

    Dexamethasone  Chemical Structure
  21. GC11237 Dexamethasone acetate

    IL Receptor modulator

    Dexamethasone acetate  Chemical Structure
  22. GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist Doxazosin Mesylate  Chemical Structure
  23. GC16994 Doxorubicin Doxorubicin(DOX), also known as adriamycin, is a compound of the anthracycline class that has the broadest spectrum of activity[1]. Doxorubicin  Chemical Structure
  24. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl  Chemical Structure
  25. GC14968 Esmolol HCl Esmolol HCl is a beta adrenergic receptor blocker. Esmolol HCl  Chemical Structure
  26. GC15617 Etoposide

    Topo II inhibitor

    Etoposide  Chemical Structure
  27. GN10156 Ginsenoside Rb1 Ginsenoside Rb1  Chemical Structure
  28. GC18049 GSK2578215A LRRK2 inhibitor GSK2578215A  Chemical Structure
  29. GA10942 H-D-Gln-OH H-D-Gln-OH  Chemical Structure
  30. GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin. Hemin chloride  Chemical Structure
  31. GC16105 Iohexol contrast agent Iohexol  Chemical Structure
  32. GC12017 Isoniazid antibiotic used for the treatment of tuberculosis Isoniazid  Chemical Structure
  33. GC64098 Isoniazid-d4 Isoniazid-d4  Chemical Structure
  34. GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator Ivermectin  Chemical Structure
  35. GC38150 Liensinine Diperchlorate Liensinine Diperchlor?ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate  Chemical Structure
  36. GC17874 Matrine An alkaloid with diverse biological activities Matrine  Chemical Structure
  37. GC10200 Mdivi 1

    A mitochondrial division inhibitor

    Mdivi 1  Chemical Structure
  38. GC15618 Melatonin Melatonin receptors agonist Melatonin  Chemical Structure
  39. GC60241 Melatonin D5 An internal standard for the quantification of melatonin Melatonin D5  Chemical Structure
  40. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin Metformin D6 hydrochloride  Chemical Structure
  41. GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin HCl  Chemical Structure
  42. GN10257 Naringin Naringin  Chemical Structure
  43. GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine  Chemical Structure
  44. GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine D3  Chemical Structure
  45. GC17580 Olaparib (AZD2281, Ku-0059436)

    A PARP inhibitor

    Olaparib (AZD2281, Ku-0059436)  Chemical Structure
  46. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)  Chemical Structure
  47. GC38562 P62-mediated mitophagy inducer P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer  Chemical Structure
  48. GN10357 Parthenolide Parthenolide  Chemical Structure
  49. GC11332 Pitavastatin

    HMG-CoA reductase inhibitor

    Pitavastatin  Chemical Structure
  50. GC12116 Pitavastatin Calcium Enzyme HMGCR inhibitor Pitavastatin Calcium  Chemical Structure
  51. GC36930 Pitavastatin D4 Pitavastatin D4 (NK-104 D4) is deuterium labeled Pitavastatin. Pitavastatin D4  Chemical Structure
  52. GN10331 Polydatin Polydatin  Chemical Structure
  53. GC15904 PP242 PP242 (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively. PP242  Chemical Structure
  54. GN10266 Quercetin

    Quercetin is an important dietary flavonoid, present in vegetables, fruits, seeds, nuts, tea and red wine.

    Quercetin  Chemical Structure
  55. GC61227 Quercetin D5 Quercetin D5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. Quercetin D5  Chemical Structure
  56. GC61229 Quinacrine dihydrochloride Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride  Chemical Structure
  57. GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride) Quinacrine dihydrochloride (Mepacrine dihydrochloride)  Chemical Structure
  58. GC14553 Resveratrol

    Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin

    Resveratrol  Chemical Structure
  59. GC14191 Ruxolitinib (INCB018424)

    Ruxolitinib (INCB018424), as an inhibitor, inhibits Janus-associated kinases (JAKs)JAK1 and JAK2 with IC50 values of 3.3 nM and 2.8 nM, respectively.

    Ruxolitinib (INCB018424)  Chemical Structure
  60. GC16124 Ruxolitinib phosphate A potent and selective JAK1/JAK2 inhibitor Ruxolitinib phosphate  Chemical Structure
  61. GC16508 Salicylic acid COX inhibitor Salicylic acid  Chemical Structure
  62. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid-d6  Chemical Structure
  63. GC14882 Salinomycin A selective cancer stem cell inhibitor Salinomycin  Chemical Structure
  64. GC13595 SB 203580 SB 203580 is a specific inhibitor of p38-MAPK (Mitogen-activated Protein Kinase) pathway [1,2]. SB 203580  Chemical Structure
  65. GC13001 SB 203580 hydrochloride Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride  Chemical Structure
  66. GC10585 Simvastatin (Zocor) Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Simvastatin (Zocor)  Chemical Structure
  67. GC31964 Sulfosuccinimidyl oleate

    Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.

    Sulfosuccinimidyl oleate  Chemical Structure
  68. GC34817 Sulfosuccinimidyl oleate sodium

    A long chain fatty acid that inhibits fatty acid transport into cells

    Sulfosuccinimidyl oleate sodium  Chemical Structure
  69. GC17651 Sunitinib RTK inhibitor Sunitinib  Chemical Structure
  70. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib Sunitinib-d10  Chemical Structure
  71. GC45099 U-0126

    A MEK inhibitor

    U-0126  Chemical Structure
  72. GC15951 URB597 An inhibitor of FAAH URB597  Chemical Structure
  73. GC11424 Valproic acid HDAC1 inhibitor Valproic acid  Chemical Structure
  74. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor Valproic acid sodium salt (Sodium valproate)  Chemical Structure
  75. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6  Chemical Structure
  76. GC17390 Vorinostat (SAHA, MK0683)

    An HDAC inhibitor

    Vorinostat (SAHA, MK0683)  Chemical Structure

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