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Mitophagy

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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products Related to Mitophagy(84)

  • GC71260 structure
    GC71260Dox-btn2
    CAS: 3026061-31-1
    Purity: >97.00%

    Dox-btn2 is a biotinylated derivative of Doxorubicin , with a biotin label at the point of conjugation to doxorubicin at 3'-NH2.

  • GC71423 structure
    GC71423ATTECs Degrader 1
    Purity: >95.00%

    ATTECs Degrader 1 (Compound MT1) is an ATTECs compound.

  • GC71451 structure
    GC71451MTX115325
    CAS: 2750895-97-5
    Purity: >99.00%

    MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity.

  • GC71492 structure
    GC71492WJ-39
    CAS: 3009908-95-3
    Purity: >99.00%

    WJ-39 is an orally active aldose reductase (AR) inhibitor.

  • GC74187 structure
    GC74187Salicylic acid-13C6
    CAS: 1189678-81-6
    Purity: >97.00%

    Salicylic acid-13C6 is the 13C-labeled Salicylic acid.

  • GC80919 structure
    GC80919AURKA-IN-4
    CAS: 89575-11-1
    Purity: >99.50%

    AURKA-IN-4 is a Capsaicin -derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A ( AURKA ) and PHB2.

  • GC81846 structure
    GC81846Nivitol
    CAS: 869743-37-3
    Purity: >98.00%

    Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor.

  • GN10156 structure
    GN10156Ginsenoside Rb1
    CAS: 41753-43-9
    Purity: >98.00%

    Ginsenoside Rb1 is a natural active ingredient extracted from ginseng that can modulate the activity of multiple signaling pathways.

  • GN10257 structure
    GN10257Naringin
    CAS: 10236-47-2
    Purity: >99.50%
  • GN10266 structure
    GN10266Quercetin
    CAS: 117-39-5
    Purity: >97.00%

    Quercetin is an important dietary flavonoid, present in vegetables, fruits, seeds, nuts, tea and red wine.

  • GN10331 structure
    GN10331Polydatin
    CAS: 27208-80-6
    Purity: >98.00%

    Polydatin is a natural stilbene glucoside extracted from the traditional Chinese medicine Polygonum cuspidatum , and Polydatin is the glycoside form of resveratrol.

  • GN10357 structure
    GN10357Parthenolide
    CAS: 20554-84-1
    Purity: >98.00%

    Parthenolide is an NF-κB inhibitor with IC 50 values for Eca109, KYSE-510, SiHa and MCF-7 cells of approximately 10.3, 13.3, 8.42 and 9.54µM at 48h respectively.