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Mitophagy

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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products Related to Mitophagy(84)

  • GC14882 structure
    GC14882Salinomycin
    CAS: 53003-10-4
    Purity: >98.00%

    A selective cancer stem cell inhibitor

  • GC14968 structure
    GC14968Esmolol HCl
    CAS: 81161-17-3
    Purity: >99.00%

    Esmolol HCl is a beta adrenergic receptor blocker.

  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    Purity: >99.50%

    Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC 50 of 2.5 μM.

  • GC15617 structure
    GC15617Etoposide
    CAS: 33419-42-0
    Purity: >98.00%

    Etoposide (VP-16) is a nonspecific inhibitor of topoisomerase II with an IC 50 value of 59.2μM.

  • GC15618 structure
    GC15618Melatonin
    CAS: 73-31-4
    Purity: >98.50%

    Melatonin receptors agonist

  • GC15706 structure
    GC15706Aspirin (Acetylsalicylic acid)
    CAS: 50-78-2
    Purity: >99.50%

    A non-selective, irreversible COX inhibitor

  • GC15794 structure
    GC15794Valproic acid sodium salt (Sodium valproate)
    CAS: 1069-66-5
    Purity: >98.00%

    Valproic acid sodium salt (Sodium valproate) (VPA) is an orally active histone deacetylase (HDAC) inhibitor with an IC 50 value of 1.5 mM. It inhibits HDAC1 with an IC 50 value of 400 μM and can induce the degradation of HDAC2.

  • GC15904 structure
    GC15904PP242
    CAS: 1092351-67-1
    Purity: >98.50%

    PP242 (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively.

  • GC15951 structure
    GC15951URB597
    CAS: 546141-08-6
    Purity: >98.00%

    URB597 is an orally active fatty acid amide hydrolase (FAAH) inhibitor (IC 50 =0.5-5nM).

  • GC16105 structure
    GC16105Iohexol
    CAS: 66108-95-0
    Purity: >98.00%

    Iohexol, a low osmolality nonionic contrast media, is a tri-iodinated benzene derivative with a molecular weight of 821.1Da.

  • GC16124 structure
    GC16124Ruxolitinib phosphate
    CAS: 1092939-17-7
    Purity: >99.50%

    A potent and selective JAK1/JAK2 inhibitor

  • GC16267 structure
    GC162676-Hydroxydopamine hydrobromide
    CAS: 636-00-0
    Purity: >98.00%

    6-Hydroxydopamine hydrobromide (6-OHDA) is a structural analogue of catecholamines, dopamine and noradrenaline, and exerts its toxic effects on catecholaminergic neurons.

  • GC16508 structure
    GC16508Salicylic acid
    CAS: 69-72-7
    Purity: >98.00%

    Salicylic acid is a natural phenolic plant defense hormone and a medicinal molecule with keratolytic activity.

  • GC16994 structure
    GC16994Doxorubicin
    CAS: 23214-92-8
    Purity: >98.00%

    Doxorubicin is an anthracycline antitumor antibiotic with broad-spectrum antitumor activity. Doxorubicin inhibits DNA topoisomerase II with an IC 50 of 2.67μM.

  • GC17234 structure
    GC17234ABT-737
    CAS: 852808-04-9
    Purity: >98.00%

    ABT-737, as a BH3 analog, is an inhibitor of the Bcl-2 family that suppresses the activity of Bcl-2, Bcl-xL, and Bcl-w, with an IC 50 value <1nM.

  • GC17340 structure
    GC17340Carbamazepine
    CAS: 298-46-4
    Purity: >99.50%

    Carbamazepine is an anticonvulsant and antiepileptic, which can decrease the release of high-frequency rhythmic action potentials.

  • GC17390 structure
    GC17390Vorinostat (SAHA, MK0683)
    CAS: 149647-78-9
    Purity: >99.00%

    An HDAC inhibitor

  • GC17443 structure
    GC17443Metformin HCl
    CAS: 1115-70-4
    Purity: >98.00%

    Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.

  • GC17567 structure
    GC17567Doxorubicin (Adriamycin) HCl
    CAS: 25316-40-9
    Purity: >98.00%

    Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.

  • GC17580 structure
    GC17580Olaparib (AZD2281, Ku-0059436)
    CAS: 763113-22-0
    Purity: >98.00%

    Olaparib (AZD2281, Ku-0059436) is a novel poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib inhibits PARP-1 (IC 50 =5nM) and PARP-2 (IC 50 =1nM) activities.

  • GC17651 structure
    GC17651Sunitinib
    CAS: 557795-19-4
    Purity: >98.00%

    Sunitinib (SU 11248) is an orally active multi-target receptor tyrosine kinase inhibitor with IC 50 values of 80 nM and 2 nM for vascular endothelial growth factor receptor (VEGFR2) and platelet-derived growth factor receptor (PDGFRβ), respectively.

  • GC17683 structure
    GC17683Brefeldin A
    CAS: 20350-15-6
    Purity: >99.50%

    Brefeldin A is a macrocyclic lactone compound derived from fungi with protein transport inhibitory activity.

  • GC17874 structure
    GC17874Matrine
    CAS: 519-02-8
    Purity: >98.00%

    Matrine is an alkaloid found in Sophora japonica plants that acts as a kappa opioid receptor and μ-receptor agonist.

  • GC18049 structure
    GC18049GSK2578215A
    CAS: 1285515-21-0
    Purity: >99.50%

    LRRK2 inhibitor