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Mitophagy

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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products Related to Mitophagy(84)

  • GC30360 structure
    GC30360Cresol (Cresol mixture of isomers)
    CAS: 1319-77-3
    Purity: >98%
  • GC30871 structure
    GC30871Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)
    CAS: 28094-15-7
    Purity: >97.00%

    Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) (6-OHDA) is an antagonist of the neurotransmitter dopamine.

  • GC31964 structure
    GC31964Sulfosuccinimidyl oleate
    CAS: 135661-44-8
    Purity: >98%

    Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.

  • GC32078 structure
    GC32078Clioquinol (Iodochlorhydroxyquin)
    CAS: 130-26-7
    Purity: >98.50%

    Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity.

  • GC32768 structure
    GC32768Quinacrine dihydrochloride (Mepacrine dihydrochloride)
    CAS: 69-05-6
    Purity: >98%
  • GC34817 structure
    GC34817Sulfosuccinimidyl oleate sodium
    CAS: 1212012-37-7
    Purity: >98.00%

    Sulfosuccinimidyl oleate sodium is an irreversible CD36 inhibitor.

  • GC36930 structure
    GC36930Pitavastatin D4
    CAS: 2070009-71-9
    Purity: >98%

    Pitavastatin D4 (NK-104 D4) is deuterium labeled Pitavastatin.

  • GC38150 structure
    GC38150Liensinine Diperchlorate
    CAS: 5088-90-4
    Purity: >98.00%

    Liensinine Diperchlor?ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn.

  • GC38562 structure
    GC38562P62-mediated mitophagy inducer
    CAS: 1809031-84-2
    Purity: >99.00%

    P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.

  • GC40226 structure
    GC40226Curcumin-d6
    CAS: 1335198-02-1
    Purity: >99.00%

    Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.

  • GC40775 structure
    GC40775Dexamethasone
    CAS: 50-02-2
    Purity: >98.00%

    Dexamethasone is a corticosteroid compound that has been used as an adjuvant to reduce postoperative pain.

  • GC45099 structure
    GC45099U-0126
    CAS: 109511-58-2
    Purity: >98.00%

    A MEK inhibitor

  • GC45356 structure
    GC453565-Aminolevulinic Acid (hydrochloride)
    CAS: 5451-09-2
    Purity: >97.00%

  • GC48118 structure
    GC48118Sunitinib-d10
    CAS: 1126721-82-1
    Purity: >99.00%

    An internal standard for the quantification of sunitinib

  • GC60241 structure
    GC60241Melatonin D5
    CAS: 66521-38-8
    Purity: >98%

    An internal standard for the quantification of melatonin

  • GC61045 structure
    GC61045Metformin D6 hydrochloride
    CAS: 1185166-01-1
    Purity: >98.00%

    An internal standard for the quantification of metformin

  • GC61227 structure
    GC61227Quercetin D5
    CAS: 263711-78-0
    Purity: >99.00%

    Quercetin D5 is a deuterated internal standard for the natural compound quercetin, its chemical structure is essentially the same as quercetin, except that five deuterium (D) atoms replace five hydrogen (H) atoms in the A ring.

  • GC61229 structure
    GC61229Quinacrine dihydrochloride
    CAS: 69-05-6
    Purity: >99.00%

    Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo.

  • GC61809 structure
    GC61809Olanzapine D3
    CAS: 786686-79-1
    Purity: >99.00%

    Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.

  • GC62135 structure
    GC62135BC1618
    CAS: 2222094-18-8
    Purity: >99.50%

    BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).

  • GC64032 structure
    GC64032Salicylic acid-d6
    CAS: 285979-87-5
    Purity: >99.50%

    Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid.

  • GC64098 structure
    GC64098Isoniazid-d4
    CAS: 774596-24-6
    Purity: >98.00%
  • GC64378 structure
    GC64378Valproic acid-d6
    CAS: 87745-18-4
    Purity: >98.00%

    Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

  • GC71203 structure
    GC71203PARL-IN-1

    PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM.