Mitophagy
Mitophagy is the selective degradation of mitochondria by autophagy.
Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.
Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.
Targets for Mitophagy
Products for Mitophagy
- Cat.No. Product Name Information
- GC11720 17-AAG (KOS953) An inhibitor of Hsp90
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GC10710
3-Methyladenine
3-Methyladenine is a classic autophagy inhibitor.
- GC45356 5-Aminolevulinic Acid (hydrochloride)
- GC16267 6-Hydroxydopamine hydrobromide Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine.
- GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins
-
GC10518
AICAR
An activator of AMPK
- GC10580 AICAR phosphate AMPK activator
- GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor
- GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
-
GC17683
Brefeldin A
Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.
- GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels
- GC15083 Celastrol A triterpenoid antioxidant
- GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol (Iodochlorhydroxyquin) (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity.
- GC30360 Cresol (Cresol mixture of isomers)
- GC14787 Curcumin A yellow pigment with diverse biological activities
- GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
-
GC13554
Deferoxamine mesylate
Deferoxamine mesylate is a drug that chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions, and is used for the treatment of chronic iron overload in patients with transfusion-dependent anemias.
-
GC40775
Dexamethasone
Dexamethasone, as one member of the glucocorticoid family, can protect against arthritis-related changes in cartilage structure and function, including matrix loss, inflammation and cartilage viability.
-
GC11237
Dexamethasone acetate
IL Receptor modulator
- GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist
- GC16994 Doxorubicin Doxorubicin(DOX), also known as adriamycin, is a compound of the anthracycline class that has the broadest spectrum of activity[1].
- GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.
- GC14968 Esmolol HCl Esmolol HCl is a beta adrenergic receptor blocker.
-
GC15617
Etoposide
Topo II inhibitor
- GN10156 Ginsenoside Rb1
- GC18049 GSK2578215A LRRK2 inhibitor
- GA10942 H-D-Gln-OH
- GC14591 Hemin chloride Hemin chloride is an iron-containing porphyrin.
- GC16105 Iohexol contrast agent
- GC12017 Isoniazid antibiotic used for the treatment of tuberculosis
- GC64098 Isoniazid-d4
- GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator
- GC38150 Liensinine Diperchlorate Liensinine Diperchlor?ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn.
- GC17874 Matrine An alkaloid with diverse biological activities
-
GC10200
Mdivi 1
A mitochondrial division inhibitor
- GC15618 Melatonin Melatonin receptors agonist
- GC60241 Melatonin D5 An internal standard for the quantification of melatonin
- GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
- GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.
- GN10257 Naringin
- GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
- GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.
-
GC17580
Olaparib (AZD2281, Ku-0059436)
A PARP inhibitor
- GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine.
- GC38562 P62-mediated mitophagy inducer P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.
- GN10357 Parthenolide
-
GC11332
Pitavastatin
HMG-CoA reductase inhibitor
- GC12116 Pitavastatin Calcium Enzyme HMGCR inhibitor
- GC36930 Pitavastatin D4 Pitavastatin D4 (NK-104 D4) is deuterium labeled Pitavastatin.
- GN10331 Polydatin
- GC15904 PP242 PP242 (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively.
-
GN10266
Quercetin
Quercetin is an important dietary flavonoid, present in vegetables, fruits, seeds, nuts, tea and red wine.
- GC61227 Quercetin D5 Quercetin D5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
- GC61229 Quinacrine dihydrochloride Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo.
- GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride)
-
GC14553
Resveratrol
Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin
-
GC14191
Ruxolitinib (INCB018424)
Ruxolitinib (INCB018424), as an inhibitor, inhibits Janus-associated kinases (JAKs)JAK1 and JAK2 with IC50 values of 3.3 nM and 2.8 nM, respectively.
- GC16124 Ruxolitinib phosphate A potent and selective JAK1/JAK2 inhibitor
- GC16508 Salicylic acid COX inhibitor
- GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid.
- GC14882 Salinomycin A selective cancer stem cell inhibitor
- GC13595 SB 203580 SB 203580 is a specific inhibitor of p38-MAPK (Mitogen-activated Protein Kinase) pathway [1,2].
- GC13001 SB 203580 hydrochloride Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively.
- GC10585 Simvastatin (Zocor) Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
-
GC31964
Sulfosuccinimidyl oleate
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.
-
GC34817
Sulfosuccinimidyl oleate sodium
A long chain fatty acid that inhibits fatty acid transport into cells
- GC17651 Sunitinib RTK inhibitor
- GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib
-
GC45099
U-0126
A MEK inhibitor
- GC15951 URB597 An inhibitor of FAAH
- GC11424 Valproic acid HDAC1 inhibitor
- GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
- GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
-
GC17390
Vorinostat (SAHA, MK0683)
An HDAC inhibitor