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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products for  Mitophagy

  1. Cat.No. Product Name Information
  2. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  3. GC10710 3-Methyladenine Class III PI3K inhibitor
  4. GC45356 5-Aminolevulinic Acid (hydrochloride)  
  5. GC16267 6-Hydroxydopamine hydrobromide neurotoxin that destroys dopaminergic and noradrenergic (catecholaminergic) neurons
  6. GC17234 ABT-737

    Bcl-2 inhibitor

  7. GC10518 AICAR AMPK activator
  8. GC10580 AICAR phosphate AMPK activator
  9. GC15706 Aspirin (Acetylsalicylic acid)

    Cyclooxygenase (COX) inhibitor

  10. GC10480 Betulinic acid

    Anti-HIV and antitumor compound,pentacyclic triterpenoid

  11. GC17683 Brefeldin A ATPase inhibitor
  12. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels
  13. GC15083 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  14. GC32078 Clioquinol (Iodochlorhydroxyquin)
  15. GC14787 Curcumin Tyrosinase inhibitor
  16. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
  17. GC13554 Deferoxamine mesylate

    iron-chelating agent

  18. GC40775 Dexamethasone Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).
  19. GC11237 Dexamethasone acetate

    IL Receptor modulator

  20. GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist
  21. GC16994 Doxorubicin

    Topo II inhibitor,immunosuppresive antineoplastic antibiotic

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