ROS

Ophthalmic Acid is an analog of glutathione (GSH) and a marker of oxidative stress and hepatic glutathione depletion.

LY2801653 (Merestinib) is a potent, orally bioavailable c-Met inhibitor (IC 50 =4.7nM; K i value=2nM), with K D values of 20nM, 92nM, and 54nM for NTRK1, NTRK2, and NTRK3, respectively.

inhibitor of the c-Met kinase and the NPM-ALK

Potent MTH1 inhibitor

4-ethylphenyl sulfate is an orally active and blood-brain barrier-penetrating intestinal microbial metabolite.

L 012 sodium salt is a luminol-based chemiluminescent probe.

Entrectinib is an orally active, blood brain barrier(BBB)-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC 50 values of 1, 3, 5, 12 and 7nM, respectively.

PF-06463922 is a novel, orally active dual inhibitor of ALK (IC 50 =15-113nM) and ROS1 (K i s=0.025-0.7nM).

Cytochrome c (from pig), a 'extreme multifunctional' protein that belongs to class 1 of the c-type cytochrome family, mediates electron-transfer in the respiratory chain and acts as a detoxifying agent to dispose of ROS and plays a role in cell apoptosis.

Cytochrome C (from horse) is an important mediator in the apoptotic pathway and has been used in various studies as an inducer of mitochondria-dependent apoptosis.

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.

DPPH (1,1-diphenyl2-picrylhydrazyl) is a stable free radical because of its spare electron delocalization over the whole molecule. The DPPH assay, which is one of the best-known, frequently employed, and accurate methods.

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

4-Vinylcyclohexene dioxide (VCD), a metabolite of 4-vinylcyclohexene (VCH), is synthesized in industries as an intermediate diluent for epoxy resins and other epoxides.

Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate) is an anionic surfactant with excellent properties in detergency, emulsification, dispersion, wetting, and foaming.

Succinyl phosphonate is a specific inhibitor of α -ketoglutarate dehydrogenase (α-KGDHC), effective inhibits KGDHC in muscle, bacterial, brain, and cultured human fibroblasts.

Temoporfin (m-THPC) is a synthetic chlorin compound with light-activated actions that acts as a potent photosensitizer.

Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

CORM-401 is a manganese-containing carbon monoxide-releasing molecule. CORM-401 can release CO in the presence of oxidants to exert anti-inflammatory and antioxidant stress effects.

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.

Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption.

α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables.

L-Sulforaphane is an orally active, non-specific activator of nuclear factor erythroid 2-related factor 2 (Nrf2), which functions by inhibiting the interaction between Keap1 protein and Nrf2.