Serine Protease
Read More about this categoryShow Less
Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.
Products Related to Serine Protease(16)
- GA20486Ac-Arg-pNA . HClCAS: 40127-26-2Purity: >99.00%
Ac-Arg-pNA . HCl is a commonly used substrate for trypsin, which is utilized for inhibitor screening or enzyme concentration determination.
- GC10027Leupeptin, MicrobialCAS: 103476-89-7Purity: >98.00%
Leupeptin, Microbial is broad-spectrum, membrane-permeable protease inhibitor that decreases protein degradation.
- GC10613Nafamostat Mesylate(FUT-175)CAS: 82956-11-4Purity: >98.00%
Nafamostat Mesylate(FUT-175) is a synthetic serine protease inhibitor.
- GC13967Tosyllysine Chloromethyl Ketone (hydrochloride)CAS: 4272-74-6Purity: >98.00%
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
- GC15682ChymostatinCAS: 9076-44-2Purity: >95.00%
Chymostatin is a potent and selective inhibitor of the proteasome chymotrypsin-like activity, with Ki values of 9.36nM for chymotrypsin and 13.1nM for cathepsin D.
- GC17711PPACKII (trifluoroacetate salt)CAS: 649748-23-2Purity: >98%
glandular and plasma kallikreins inhibitor
- GC26017UK-371804 HClCAS: 256476-36-5Purity: >98%
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
- GC90893Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)CAS: 2005478-89-5Purity: >95.00%
An isomer of ADP-α-S
- GC90894Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)CAS: 2005478-90-8Purity: >95.00%
An isomer of ADP-α-S
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GA20486 | Ac-Arg-pNA . HCl | 40127-26-2 | >99.00% | |
Ac-Arg-pNA . HCl is a commonly used substrate for trypsin, which is utilized for inhibitor screening or enzyme concentration determination. | ||||
| GC10027 | Leupeptin, Microbial | 103476-89-7 | >98.00% | |
Leupeptin, Microbial is broad-spectrum, membrane-permeable protease inhibitor that decreases protein degradation. | ||||
| GC10477 | PMSF | 329-98-6 | >98.00% | |
PMSF is an irreversible serine protease inhibitor that is often added to the lysis buffer before cell or tissue lysis to prevent protein degradation. | ||||
| GC10613 | Nafamostat Mesylate(FUT-175) | 82956-11-4 | >98.00% | |
Nafamostat Mesylate(FUT-175) is a synthetic serine protease inhibitor. | ||||
| GC12900 | Aprotinin | 9087-70-1 | - | |
Aprotininis a naturally occurring serine protease inhibitor that inhibits plasmin and kallikrein with K i values of 0.07nM and 36nM, respectively. | ||||
| GC13421 | UCF 101 | 313649-08-0 | >98.00% | |
inhibitor of the proteolytic activity of Omi/HtrA2 | ||||
| GC13967 | Tosyllysine Chloromethyl Ketone (hydrochloride) | 4272-74-6 | >98.00% | |
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death. | ||||
| GC14502 | AEBSF.HCl | 30827-99-7 | >98.00% | |
AEBSF.HCl is a broad-spectrum, irreversible inhibitor of serine proteases, capable of inhibiting trypsin, kallikrein, plasmin, thrombin, chymotrypsin, and related thrombolytic enzymes. | ||||
| GC15682 | Chymostatin | 9076-44-2 | >95.00% | |
Chymostatin is a potent and selective inhibitor of the proteasome chymotrypsin-like activity, with Ki values of 9.36nM for chymotrypsin and 13.1nM for cathepsin D. | ||||
| GC17711 | PPACKII (trifluoroacetate salt) | 649748-23-2 | >98% | |
glandular and plasma kallikreins inhibitor | ||||
| GC26017 | UK-371804 HCl | 256476-36-5 | >98% | |
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). | ||||
| GC39256 | LP-935509 | 1454555-29-3 | >99.50% | |
LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively. | ||||
| GC49221 | QLT0267 | 866409-68-9 | >98.00% | |
An ILK inhibitor | ||||
| GC69422 | M4K2234 | 2421141-51-5 | >98.00% | |
M4K2234 (compound 26b) is an inhibitor of ALK2. M4K2234 inhibits ALK2 and ALK5 with IC50 values of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for the protein kinases ALK1 and ALK2. M4K2234 can be used in cancer research. | ||||
| GC90893 | Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt) | 2005478-89-5 | >95.00% | |
An isomer of ADP-α-S | ||||
| GC90894 | Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt) | 2005478-90-8 | >95.00% | |
An isomer of ADP-α-S | ||||