Sigma Receptor
Sigma receptors are non-opioid receptors that interacted with psychostimulants such as cocaine and methamphetamine. It is associated with central nervous systems diseases, cancer and neuropathic pain etc.
Products Related to Sigma Receptor(59)
- GC11187PD 144418 oxalateCAS: 154130-99-1Purity: >98%
PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively).
- GC13083SiramesineCAS: 147817-50-3Purity: >98%
Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.
- GC14960PRE-084 hydrochlorideCAS: 75136-54-8Purity: >99.50%
PRE-084 hydrochloride is a highly selective sigma-1 receptor (S1R) agonist with an IC 50 value of 44nM.
- GC15465N-[2-(Piperidinylamino)ethyl]-4-iodobenzamideCAS: 155054-42-5Purity: >98%
σ-1 selective ligand
- GC15838BD 1063 dihydrochlorideCAS: 206996-13-6Purity: >98.00%
BD 1063 dihydrochloride is a potent and selective sigma 1 receptor antagonist.
- GC16004NE 100 hydrochlorideCAS: 149409-57-4Purity: >98.00%
NE 100 hydrochloride is a selective sigma-1 receptor antagonist (IC₅₀=4.16nM).
- GC17088SA 4503 dihydrochlorideCAS: 165377-44-6Purity: >98.00%
SA 4503 dihydrochloride is a highly selective σ1 receptor agonist with an IC 50 value of 17nM.
- GC15222Siramesine hydrochlorideCAS: 224177-60-0Purity: >99.50%
Siramesine hydrochloride is an effective sigma-2 receptor agonist. Siramesine has an annanometer-level affinity for the sigma-2 receptor (IC 50 = 0.12nM), and its selectivity for the sigma-2 receptor is 140 times that of the sigma-1 receptor (IC 50 = 17nM).
- GC16595BD 1008 dihydrobromideCAS: 138356-09-9Purity: >98%
δ1-receptor antagonist,potent and selective
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10407 | S1RA | 878141-96-9 | >98% | |
σ1R antagonist | ||||
| GC10795 | Rimcazole dihydrochloride | 75859-03-9 | >99.50% | |
σ receptors antagonist | ||||
| GC11187 | PD 144418 oxalate | 154130-99-1 | >98% | |
PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). | ||||
| GC13083 | Siramesine | 147817-50-3 | >98% | |
Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity. | ||||
| GC13911 | S1RA hydrochloride | 1265917-14-3 | >99.00% | |
σ1R antagonist | ||||
| GC14960 | PRE-084 hydrochloride | 75136-54-8 | >99.50% | |
PRE-084 hydrochloride is a highly selective sigma-1 receptor (S1R) agonist with an IC 50 value of 44nM. | ||||
| GC15144 | (±)-PPCC oxalate | 932736-90-8 | >98% | |
sigma (σ) receptor ligand | ||||
| GC15374 | BD 1047 dihydrobromide | 138356-21-5 | >98.00% | |
σ1 receptor antagonist | ||||
| GC15465 | N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide | 155054-42-5 | >98% | |
σ-1 selective ligand | ||||
| GC15838 | BD 1063 dihydrochloride | 206996-13-6 | >98.00% | |
BD 1063 dihydrochloride is a potent and selective sigma 1 receptor antagonist. | ||||
| GC16004 | NE 100 hydrochloride | 149409-57-4 | >98.00% | |
NE 100 hydrochloride is a selective sigma-1 receptor antagonist (IC₅₀=4.16nM). | ||||
| GC16473 | TC 1 | 362512-81-0 | >98% | |
σ1 receptor ligand | ||||
| GC17088 | SA 4503 dihydrochloride | 165377-44-6 | >98.00% | |
SA 4503 dihydrochloride is a highly selective σ1 receptor agonist with an IC 50 value of 17nM. | ||||
| GC17301 | (+)-SK&F 10047 hydrochloride | 133005-41-1 | >98% | |
prototypical σ1 receptor agonist | ||||
| GC17392 | PB 28 dihydrochloride | 172907-03-8 | >99.50% | |
σ2 receptor agonist | ||||
| GC17723 | 4-IBP | 155798-08-6 | >98.00% | |
σ1 agonist | ||||
| GC18146 | (+)-Igmesine hydrochloride | 130152-35-1 | >98% | |
σ1 receptor ligand | ||||
| GC12490 | L-693,403 maleate | 137730-52-0 | >98% | |
High affinity σ ligand | ||||
| GC13357 | 4-PPBP maleate | 201216-39-9 | >98% | |
σ ligand and NR1a/2B NMDA receptors antagonist | ||||
| GC13796 | BMY 14802 hydrochloride | 105565-55-7 | >98% | |
Sigma receptor antagonist | ||||
| GC14249 | UNC 0642 | 1481677-78-4 | >99.50% | |
G9a and GLP histone lysine methyltransferase inhibitor | ||||
| GC15222 | Siramesine hydrochloride | 224177-60-0 | >99.50% | |
Siramesine hydrochloride is an effective sigma-2 receptor agonist. Siramesine has an annanometer-level affinity for the sigma-2 receptor (IC 50 = 0.12nM), and its selectivity for the sigma-2 receptor is 140 times that of the sigma-1 receptor (IC 50 = 17nM). | ||||
| GC16595 | BD 1008 dihydrobromide | 138356-09-9 | >98% | |
δ1-receptor antagonist,potent and selective | ||||
| GC16598 | DTG | 97-39-2 | >99.00% | |
DTG (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor). | ||||