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DTG (Synonyms: NSC 132023, DTG, NSC 473)

Catalog No.GC16598

DTG (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).

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DTG Chemical Structure

Cas No.: 97-39-2

Size Price Stock Qty
1g
$45.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor)[1].

References:
[1]. Skuza G, et al. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

Chemical Properties

Cas No. 97-39-2 SDF
Synonyms NSC 132023, DTG, NSC 473
Chemical Name (E)-1,2-di-o-tolylguanidine
Canonical SMILES N/C(NC1=CC=CC=C1C)=N\C2=CC=CC=C2C
Formula C15H17N3 M.Wt 239.32
Solubility <5.98mg/ml in DMSO; <5.98mg/ml in ethanol Storage Store at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.1785 mL 20.8925 mL 41.7851 mL
5 mM 0.8357 mL 4.1785 mL 8.357 mL
10 mM 0.4179 mL 2.0893 mL 4.1785 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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