Sigma Receptor
Sigma receptors are non-opioid receptors that interacted with psychostimulants such as cocaine and methamphetamine. It is associated with central nervous systems diseases, cancer and neuropathic pain etc.
Products Related to Sigma Receptor(59)
- GC19032AVex-73 hydrochlorideCAS: 195615-84-0Purity: >98.00%
AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
- GC30206Roluperidone (CYR-101)CAS: 359625-79-9Purity: >99.50%
Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).
- GC30956Dimemorfan phosphateCAS: 36304-84-4Purity: >99.50%
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
- GC31294Sigma-LIGAND-1CAS: 139652-01-0Purity: >98%
Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.
- GC33697Cutamesine (SA4503)CAS: 165377-43-5Purity: >98%
Cutamesine (SA4503) is a potent and selective agonist for the sigma 1 receptor subtype in the brain.
- GC38038Sigma-1 receptor antagonist 1CAS: 1639220-19-1Purity: >99.50%
Sigma?1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM).
- GC38039Sigma-1 receptor antagonist 2CAS: 1639220-15-7Purity: >99.50%
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively.
- GC38048Sigma-1 receptor antagonist 3CAS: 1639220-17-9Purity: >99.00%
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM.
- GC38712(2R,3R)-E1RCAS: 1400888-63-2Purity: >98.50%
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R.
- GC38713(2R,3S)-E1RCAS: 1424832-60-9Purity: >98.50%
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R.
- GC38714(2S,3S)-E1RCAS: 1424832-57-4Purity: >98.00%
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R.
- GC60216KB-5492 anhydrousCAS: 129200-10-8Purity: >99.50%
KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM.
- GC61838PentoxyverineCAS: 77-23-6Purity: >98.00%
Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes.
- GC61889OPC-14523 hydrochlorideCAS: 145969-31-9Purity: >99.50%
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).
- GC61926PanamesineCAS: 139225-22-2Purity: >99.50%
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites.
- GC62708σ1 Receptor antagonist-1CAS: 1204401-49-9Purity: >98.00%
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28).
- GC62959EST64454 hydrochlorideCAS: 1950569-11-5Purity: >99.00%
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC17380 | Metaphit | 96316-00-6 | >98% | |
Acylator of PCP and σ-receptors | ||||
| GC17721 | IPAG | 193527-91-2 | >98% | |
Potent σ-receptor antagonist | ||||
| GC19032 | AVex-73 hydrochloride | 195615-84-0 | >98.00% | |
AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. | ||||
| GC30206 | Roluperidone (CYR-101) | 359625-79-9 | >99.50% | |
Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively). | ||||
| GC30956 | Dimemorfan phosphate | 36304-84-4 | >99.50% | |
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive. | ||||
| GC31294 | Sigma-LIGAND-1 | 139652-01-0 | >98% | |
Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. | ||||
| GC32821 | Noscapine ((S,R)-Noscapine) | 128-62-1 | >98% | |
| GC33697 | Cutamesine (SA4503) | 165377-43-5 | >98% | |
Cutamesine (SA4503) is a potent and selective agonist for the sigma 1 receptor subtype in the brain. | ||||
| GC35923 | E1R | 1301211-78-8 | >99.00% | |
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity. | ||||
| GC38038 | Sigma-1 receptor antagonist 1 | 1639220-19-1 | >99.50% | |
Sigma?1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). | ||||
| GC38039 | Sigma-1 receptor antagonist 2 | 1639220-15-7 | >99.50% | |
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively. | ||||
| GC38048 | Sigma-1 receptor antagonist 3 | 1639220-17-9 | >99.00% | |
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. | ||||
| GC38712 | (2R,3R)-E1R | 1400888-63-2 | >98.50% | |
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. | ||||
| GC38713 | (2R,3S)-E1R | 1424832-60-9 | >98.50% | |
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. | ||||
| GC38714 | (2S,3S)-E1R | 1424832-57-4 | >98.00% | |
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. | ||||
| GC38721 | (Rac)-E1R | 787623-60-3 | >98.00% | |
(Rac)-E1R (Compound 2) is the racemate of E1R. | ||||
| GC50048 | (+/-)-PPCC oxalate | 932736-91-9 | >98% | |
Selective sigma (σ) agonist (σ1> σ2) | ||||
| GC60216 | KB-5492 anhydrous | 129200-10-8 | >99.50% | |
KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. | ||||
| GC61822 | DuP 734 | 135135-87-4 | >98.00% | |
DuP 734 is a sigma receptor antagonist. | ||||
| GC61838 | Pentoxyverine | 77-23-6 | >98.00% | |
Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. | ||||
| GC61889 | OPC-14523 hydrochloride | 145969-31-9 | >99.50% | |
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). | ||||
| GC61926 | Panamesine | 139225-22-2 | >99.50% | |
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. | ||||
| GC62708 | σ1 Receptor antagonist-1 | 1204401-49-9 | >98.00% | |
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). | ||||
| GC62959 | EST64454 hydrochloride | 1950569-11-5 | >99.00% | |
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. | ||||