GLPBio

Smoothened

Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.

Products Related to Smoothened(36)

  • GC11111 structure
    GC11111Jervine
    CAS: 469-59-0
    Purity: >99.00%

    Hedgehog signaling Inhibitor

  • GC11217 structure
    GC11217CUR 61414
    CAS: 334998-36-6
    Purity: >99.00%

    potent inhibitor of hedgehog-induced cellular activity

  • GC12068 structure
    GC12068SAG
    CAS: 912545-86-9
    Purity: >99.50%

    SAG (Smoothened Agonist) is an effective Smo receptor agonist.

  • GC12192 structure
    GC12192MRT 10
    CAS: 330829-30-6
    Purity: >98%

    MRT 10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT 10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT 10 can be used for the research of cancer.

  • GC12228 structure
    GC12228SMANT hydrochloride
    CAS: 1177600-74-6
    Purity: >98%

    Smoothened (Smo) signaling inhibitor

  • GC12951 structure
    GC12951HhAntag
    CAS: 496794-70-8
    Purity: >98.50%

    A hedgehog pathway inhibitor

  • GC13041 structure
    GC13041M 25
    Purity: >98%

    Smoothened (Smo) receptor antagonist

  • GC13280 structure
    GC13280PF-5274857
    CAS: 1373615-35-0
    Purity: >98.00%

    Smo antagonist,potent and selective

  • GC13628 structure
    GC13628BMS-833923
    CAS: 1059734-66-5
    Purity: >98.00%

    An orally bioavailable Smo inhibitor

  • GC13630 structure
    GC13630MK-4101
    CAS: 935273-79-3
    Purity: >98.00%

    Hedgehog (Hh) signaling pathway inhibitor

  • GC14169 structure
    GC14169LDE225 Diphosphate
    CAS: 1218778-77-8
    Purity: >99.50%

    A Smo antagonist

  • GC14640 structure
    GC14640GSA 10
    CAS: 300833-95-8
    Purity: >95.00%

    Smoothened (Smo) receptor agonist

  • GC14749 structure
    GC14749ALLO-1
    CAS: 37468-32-9
    Purity: >98%

    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.

  • GC14896 structure
    GC14896Halcinonide
    CAS: 3093-35-4
    Purity: >98.00%

    Anti-inflammatory agent

  • GC15064 structure
    GC15064Purmorphamine
    CAS: 483367-10-8
    Purity: >98.00%

    Purmorphamine is the first small molecule agonist developed for Smoothened protein.

  • GC15422 structure
    GC1542220(S)-Hydroxycholesterol
    CAS: 516-72-3
    Purity: >98.00%

    20(S)-Hydroxycholesterol is a selective allosteric activator of the Hedgehog pathway protein Smoothened (EC 50 =3μM).

  • GC15683 structure
    GC15683LY2940680
    CAS: 1258861-20-9
    Purity: >99.50%

    LY2940680 (LY2940680) is an antagonist of the smoothened receptor.

  • GC15889 structure
    GC15889SANT-1
    CAS: 304909-07-7
    Purity: >99.50%

    SANT-1 is a cell-permeable Smoothened antagonist that inhibits the Hedgehog pathway.

  • GC16230 structure
    GC16230PF-04449913
    CAS: 1095173-27-5
    Purity: >98.00%

    PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.

  • GC18599 structure
    GC18599PF-05274857 (hydrochloride)
    CAS: 1613439-62-5
    Purity: >98%

    PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

  • GC32954 structure
    GC32954LEQ506 (NVP-LEQ506)
    CAS: 1204975-42-7
    Purity: >98.00%

    LEQ506 (NVP-LEQ506) is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.

  • GC32978 structure
    GC32978Saridegib (IPI-926)
    CAS: 1037210-93-7
    Purity: >99.00%

    Saridegib (IPI-926) is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

  • GC33114 structure
    GC33114MRT-83
    CAS: 1263131-92-5
    Purity: >98%

    MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

  • GC34463 structure
    GC34463ALLO-2
    CAS: 1357350-60-7
    Purity: >99.50%

    ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.