Enzymes

(R)-Azasetron besylate SENS-401 es un inhibidor de la calcineurina.

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a fluorescently quenched peptide substrate that can be used to detect the activity of matrix metalloproteinases (MMPs) and their associated tumor necrosis factor converting enzyme (TACE) (Ex/Em=325nm/400nm).

AV5116 is a cap-dependent endonuclease inhibitor ( CENI ) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic.

Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC 50 of 1.4 μM.

Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis [1] .

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS ), non-covalent pan- KRAS inhibitor ( IC 50 =28-120 nM).

RM-046 is an orally active, selective ternary complex inhibitor of KRAS Q61H (active form).

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

ZX-J-19L is a CyPJ inhibitor with inhibitory activity against a variety of tumor cell lines.

DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor ( IC 50 =0.47 μM), and also exhibits certain inhibitory activity against KLK5 and KLK7 ( IC 50 values are 1.1 nM and 73 nM, respectively).

KVD-001 is a potent plasma kallikrein inhibitor.

IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.

PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.

PTPRO-IN-1 is a selective, orally active PTPRO inhibitor with an IC 50 of 0.16 μM.

Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L.

LacCer (d18:1/20:0) is a lipid whose level is closely associated with atherosclerosis and cardiovascular diseases [1] .

MMP-9-IN-13 (Example 1) is a selective inhibitor of human MMP9 with an IC 50 value of 0.02 nM.

C-telopeptide acetate is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD).

Dnp-PLGLWAr-NH2 acetate is a synthetic collagenase/gelatinase substrate.

BT1769 acetate is a conjugate and antitumor agent targeting MT1-MMP, with a K d value of 3.35 nM against human targets.

(R,S)-Phosphonsaeure (Compound 2A) is an inhibitor of prostatic acid phosphatase with an IC 50 value of 4 nM.

ML 086 is a highly selective PHOSPHO1 phosphatase inhibitor ( IC 50 =0.14 μM).

KF-52 enantiomer is an enantiomer of KF-52.

Anti-Rat pan-CD45 Antibody (OX1) reacts with a common epitope present on all isotypes of rat CD45.