BT1769 acetate |
Catalog No.GC79717
One-Click Copy Product Info
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BT1769 acetate is a conjugate and antitumor agent targeting MT1-MMP, with a K d value of 3.35 nM against human targets.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vivo, BT1769 (acetate) (3.2 mg/kg; i.v.; once weekly) induces significant antitumor activity in HT1080 osteosarcoma xenografts in female BALB/c nude mice[2]. BT1769 (acetate) (3 mg/kg; i.v.; once weekly; 4 weeks) significantly prolongs event-free survival and induces maintained complete responses in most tested osteosarcoma patient-derived xenograft models in female CB17SC scid-/- mice[2].
In Vitro, BT1769 acetate (1.5625-100 nnM) binds to recombinant human MT1-MMP with a KD of 3.35 nM and to recombinant mouse MT1-MMP with a KD of 2.99 nM, showing high target affinity[2].
References:
[1]. Wang Y, et al. Abstract LB008: Integrative surfaceome profiling identifies immunotherapeutic targets in osteosarcomas (OS); Preclinical testing of BT1769, an MT1-MMP-targeted Bicycle Toxin Conjugate, in OS by the Pediatric Preclinical Testing Consortium (PPTC)[J]. Cancer Research, 2021, 81(13_Supplement): LB008-LB008.
[2]. Wang Y, et al. Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma. Mol Cancer Ther. 2022;21(6):903-913.
| Cas No. | SDF | ||
| Formula | C186H269N43O50S·xC2H4O2 | M.Wt | 3939.45 |
| Solubility | H2O: 50 mg/mL (Need ultrasonic) | Storage | Sealed storage, away from moisture |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 253.8 μL | 1.2692 mL | 2.5384 mL |
| 5 mM | 50.8 μL | 253.8 μL | 507.7 μL |
| 10 mM | 25.4 μL | 126.9 μL | 253.8 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)