GLPBio

E1/E2/E3 Enzyme

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Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

Products Related to E1/E2/E3 Enzyme(125)

  • GC71320 structure
    GC71320Cbl-b-IN-5
    CAS: 2368835-59-8
    Purity: >99.00%

    Cbl-b-IN-5 (compuesto 6) es un inhibidor de Cbl-b (IC50=3-10 − M).

  • GC73155 structure
    GC73155Rugonersen sodium
    CAS: 2591588-58-6
    Purity: >91.00%

    Rugonersen sodium es un ácido nuclebloqueado (LNA)- oligonucleótidos antisentido modificados (ASOs), y resulta en la reducción de la ubiquitin-proteína ligasa E3A (UBE3A) silenci.

  • GC73229 structure
    GC73229Smurf1-IN-1
    CAS: 1824708-03-3
    Purity: >99.00%

    Smurf1-IN-1 es un inhibidor activo y selectivo de la proteína ligasa 1 de ubiquitina E3 específica (SMURF1) con una IC50 de 92 nM.

  • GC73363 structure
    GC73363Antitumor agent-81
    CAS: 2765180-17-2
    Purity: >98.00%

    Antitumor agent-81 (compuesto 5a) es un agonista de baja citotoxicidad P62-RNF168 que mejora la interacción entre P62 y RNF168.

  • GC73485 structure
    GC73485UC-764864
    CAS: 278806-03-4
    Purity: >99.00%

    UC-764864 es un inhibidor de UBE2N.

  • GC73512 structure
    GC73512Skp2 inhibitor 2
    CAS: 2760612-77-7

    Skp2 inhibitor 2 (14f) es un inhibide la proteína F-box proteína asociada a cinasa fase s proteína 2 (Skp2), con un valor de IC50 de 10,2 μM (Skp2-Cks1).

  • GC73748 structure
    GC73748PELI1-IN-1
    Purity: >98.00%

    PELI1-IN-1 (compuesto 3d) es un potente inhibidor de PELI1, E3 ubiquitina ligasa.

  • GC73800 structure
    GC73800MS181
    Purity: >98.00%

    MS181 (compuesto 1) es un potente cereblon (CRBN) -reclutamiento y EED-binding polycomb represicomplex 1 (PRC1) PROTAC degrader.

  • GC73900 structure
    GC73900HA-9104
    CAS: 2412367-83-8
    Purity: >98.00%

    HA-9104 es un potente y selectivo inhibidor de cullin-5 neddylation a través de prácticamente dirigido a la V30 bolsillo de UBE2F.

  • GC74157 structure
    GC74157EN450
    CAS: 793719-01-4
    Purity: >99.00%

    EN450 es un degrador de cola molecular covalente reactivo a cisteína que apunta a NF- − B.

  • GC79075 structure
    GC79075NVS1.1
    Purity: >98.00%

    NVS1.1 is an orally active, blood-brain barrier-penetrant eRF1 degrader.

  • GC79626 structure
    GC79626H111-H7
    CAS: 220965-54-8
    Purity: >98.00%

    H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 ( WWP2 ) inhibitor with a K D of 717 nM.

  • GC79627 structure
    GC79627H36-E4
    CAS: 688310-17-0
    Purity: >98.50%

    H36-E4 is a WW domain containing E3 ubiquitin 27 protein ligase 2 ( WWP2 ) inhibitor with a K D of 6.25 μM.

  • GC79628 structure
    GC79628XMU-MP-10
    CAS: 2251132-02-0
    Purity: >98.00%

    XMU-MP-10 is a selective NEDD4 inhibitor with a K D of 43.92 nM.

  • GC79629 structure
    GC79629ZER1 binder-2
    CAS: 3132618-63-1
    Purity: >98.00%

    ZER1 binder-2 is a ZER1 E3 ubiquitin ligase binder with an EC 50 value of 51.04 nM.

  • GC79630 structure
    GC79630MRC37
    Purity: >98.50%

    MRC37 is a high-affinity TRIM21 ligand with a K d of 0.4 µM.

  • GC79631 structure
    GC79631JWP24 acetate
    Purity: >98.00%

    JWP24 acetate is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC 50 of 200 nM against human MAGE-A4.

  • GC79725 structure
    GC79725DI-1548
    CAS: 2247060-97-3
    Purity: >98.00%

    DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).

  • GC79727 structure
    GC79727Tracer AL244
    Purity: >98.50%

    Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder.

  • GC80879 structure
    GC80879JWZ-8-103 hydrochloride
    Purity: >99.50%

    JWZ-8-103 hydrochloride is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21.

  • GC80921 structure
    GC80921CCT400028
    Purity: >98.00%

    CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase.

  • GC81022 structure
    GC81022JWZ-8-103
    CAS: 3110272-60-8
    Purity: >98.00%

    JWZ-8-103 is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21.

  • GC81024 structure
    GC81024PROTAC RNF4 degrader-1
    Purity: >98.00%

    PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.