SJ3149 |
Catalog No.GC73870
One-Click Copy Product Info
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SJ3149 es un degrader selectivo y potente in vitro ein vivo de proteína CK1α con amplia actividad antiproliferativa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3026986-17-1
Sample solution is provided at 25 µL, 10mM.
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SJ3149 is a selective and potent in vitro and in vivo degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research.
SJ3149 (1 nM-10 µM; 4 h) degrades CK1α protein in MOLM-13 cells by 50 % at a concentration of 4 nM, while at a dose of 10 μM, the level of IKZF2 in the cells is only reduced by about 40 %[1]. SJ3149 inhibits the growth of MOLM-13 cells with an IC50 of 14 nM and reduces CK1a abundance with a DC50 value of 11 nM and a Dmax value of 88 %[2].
SJ3149 (50 mg/kg; i.p.; once a day for 2 days or twice a day for 2 days) significantly degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells[1].
References:
[1]. Nishiguchi G, et al. Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat Commun. 2024 Jan 16;15(1):482.
[2]. Rankovic Z, et al. Rationally Designed Potent and Selective CK1α Degraders Exert Antiproliferative Activity Against a Broad Range of Human Cancer Cell Lines[J]. 2023.
| Cas No. | 3026986-17-1 | SDF | |
| Formula | C20H16N4O4 | M.Wt | 376.37 |
| Solubility | DMSO : 75 mg/mL (199.27 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.657 mL | 13.2848 mL | 26.5696 mL |
| 5 mM | 531.4 μL | 2.657 mL | 5.3139 mL |
| 10 mM | 265.7 μL | 1.3285 mL | 2.657 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)