GLPBio

TDI-012804

Catalog No.: GC84184Purity:>99.50%
COASDSData Sheet
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

TDI-012804
Cas No.: 3120102-92-0
10mM (in 1mL DMSO)In Stock
$1,846.00
1
1mgIn Stock
$576.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

Actualmente no hay citas disponibles para este producto. A continuación se muestran publicaciones seleccionadas que citan productos GlpBio.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Descripción (Description)

TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids ( EC 50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids [1].

References:
[1]. Jill Zimmerman, et al. A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression. bioRxiv.2025 Mar 7:2025.03.04.641305.

Documentos del producto (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
3120102-92-0
Fórmula molecular
C30H26N4O4
Peso molecular
506.55
Solubilidad
DMSO: 100 mg/mL (197.41 mM; Need ultrasonic)
Almacenamiento
Store at 4°C, sealed storage, away from moisture
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

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