Sphingolipids

C6 Ceramide (d18:1/6:0) is a short-chain, cell-permeable analog of ceramide that has been utilized in preclinical studies to mimic the effects of endogenous ceramide.

Fumonisin B1 is a mycotoxin produced from F. moniliforme, a prevalent fungus of corn and other grains.

Sphingomyelins are a dominant sphingolipid in membranes of mammalian cells, and this lipid class is specifically enriched in the plasma membrane.

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with hydroxy and non-hydroxy fatty acids.

1-Deoxysphinganine (m18:0) (ES-285) is an antiproliferative (antitumoral) compound of marine origin. 1-Deoxysphinganine (m18:0) inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation.

CAY10444 is a sphingosine-1-phosphate receptor 3 (S1P3) antagonist. CAY10444 can inhibit calcium ion release caused by S1P in CHO cells expressing human S1P3 (IC 50 value is 11.6μM).

Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane.

Sphingosine-d7 (d18:1) (Erythrosphingosine-d7) is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.

C18 3'-sulfo Lactosylceramide (d18:1/18:0) is a sulfated glycosphingolipid.

C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS.

Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid.

C6 dihydro 1-Deoxyceramide (m18:0/6:0) is a short-chain atypical ceramide containing a 1-deoxysphinganine (m18:0) backbone.

C6 1-Deoxyceramide (m18:1(14Z)/6:0) is a short-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(14Z)) backbone with a cis double bond at the 14-15 position rather than a trans double bond at the 4-5 position.

D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM).

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM).

C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

C6 L-threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

C2 L-erythro Ceramide is a bioactive sphingolipid and a cell-permeable analog of naturally occurring ceramides.

C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

An S1P 1 receptor agonist

L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1).