GLPBio

SPHK

SPHK (sphingosine kinase) is a conserved lipid kinase that catalyzes formation S1P (sphingosine-1-phosphate) from the precursor sphingolipid sphingosine.

Products Related to SPHK(18)

  • GC12581 structure
    GC12581K145
    CAS: 1309444-75-4
    Purity: >98.00%

    K145 is a selective sphingosine kinase 2 (SphK2) inhibitor with an IC 50 value of 4.3μM and a K i value of 6.4μM, exhibiting anticancer activity.

  • GC10154 structure
    GC10154ABC294640
    CAS: 915385-81-8
    Purity: >99.50%

    ABC294640 (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.

  • GC11917 structure
    GC11917PF-543
    CAS: 1415562-82-1
    Purity: >98.00%

    PF-543 is a potent, selective, reversible, and sphingosine-competitive inhibitor of SphK1 with an IC 50 value of 2nM and a Ki value of 3.6 nM.

  • GC16352 structure
    GC16352PF-543 Citrate
    CAS: 1415562-83-2
    Purity: >98.00%
  • GC16701 structure
    GC16701SKI II
    CAS: 312636-16-1
    Purity: >98.00%

    Sphingosine kinase(SK) inhibitor

  • GC19501 structure
    GC19501MHP
    CAS: 1104874-94-3
    Purity: >98.50%

    MHP is an activator of sphingosine kinase (SPHK1)

  • GC32107 structure
    GC32107Peretinoin (NIK333)
    CAS: 81485-25-8
    Purity: >99.00%

    Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR).

  • GC33016 structure
    GC33016MP-A08
    CAS: 219832-49-2
    Purity: >98.00%

    An inhibitor of SK1 and SK2

  • GC33836 structure
    GC33836SK1-IN-1
    CAS: 1218816-71-7
    Purity: >98.50%

    SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.

  • GC36372 structure
    GC36372K145 hydrochloride
    CAS: 1449240-68-9
    Purity: >98.00%

    K145 hydrochloride is a selective sphingosine kinase 2 (SphK2) inhibitor with an IC 50 value of 4.3μM and a K i value of 6.4μM, exhibiting anticancer activity.

  • GC44896 structure
    GC44896SKI 178
    CAS: 1259484-97-3
    Purity: >98.00%

    SKI 178 is a non-selective inhibitor of Sphingosine Kinases (SphK1 and SphK2).

  • GC50253 structure
    GC50253PF 543 hydrochloride
    CAS: 1706522-79-3
    Purity: >98.00%

    Potent and selective SphK1 inhibitor

  • GC60339 structure
    GC60339SKI V
    CAS: 24418-86-8
    Purity: >98.00%

    SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity.

  • GC61597 structure
    GC61597SK1-I
    CAS: 1072443-89-0
    Purity: >98%

    SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 ?M. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity.

  • GC66011 structure
    GC66011SKI-I
    CAS: 306301-68-8
    Purity: >99.00%

    SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines.

  • GC68650 structure
    GC68650Amgen-23
    CAS: 1448706-15-7
    Purity: >99.00%

    Amgen-23 (compound 23) is an effective inhibitor of sphingosine kinase (SPHK), with IC50 values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used in cancer research.

  • GC73974 structure
    GC73974SKI-349
    CAS: 727686-80-8
    Purity: >99.50%

    SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA).

  • GN10444 structure
    GN1044412-O-tetradecanoyl phorbol-13-acetate
    CAS: 16561-29-8
    Purity: >98.00%

    A PKC activator