GLPBio

Tasquinimod-d3

Catalog No.: GC72782Purity:>99.00%Synonyms: ABR-215050-d3
COASDSData Sheet
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod.

Products are for research use only. Not for human use. We do not sell to patients.

Tasquinimod-d3
Cas No.: 1416701-99-9
1 mgIn Stock
$180.00
1
5 mgIn Stock
$468.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod . Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor.

References:
[1]. Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99.
[2]. Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106.
[3]. Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1416701-99-9
Synonyms
ABR-215050-d3
Molecular Formula
C20H14D3F3N2O4
Molecular Weight
409.37
Solubility
DMSO : 100 mg/mL (244.28 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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