GLPBio

Transferase

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Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

Products Related to Transferase(21)

  • GC10106 structure
    GC10106OR-486
    CAS: 7659-29-2
    Purity: >98%

    OR-486 (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM.

  • GC10265 structure
    GC10265Manumycin A
    CAS: 52665-74-4
    Purity: >98.00%

    farnesyltransferase inhibitor

  • GC10330 structure
    GC10330Lonafarnib
    CAS: 193275-84-2
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC10905 structure
    GC10905Amodiaquine dihydrochloride dihydrate
    CAS: 6398-98-7
    Purity: >99.50%

    histamine N-methyl transferase inhibitor

  • GC11524 structure
    GC11524Cystamine dihydrochloride
    CAS: 56-17-7
    Purity: >98%

    transglutaminase inhibitor

  • GC11884 structure
    GC11884GPP 78 hydrochloride
    Purity: >98%

    NAMPT inhibitor

  • GC12449 structure
    GC12449SKF 91488 dihydrochloride
    CAS: 68941-21-9
    Purity: >98%

    histamine N-methyltransferase inhibitor

  • GC12912 structure
    GC12912BCATc Inhibitor 2
    CAS: 406191-34-2
    Purity: >99.00%

    cytosolic BCAT (BCATc) inhibitor

  • GC12981 structure
    GC12981OU749
    CAS: 519170-13-9
    Purity: >98%

    γ-Glutamyl transferase (GGT) inhibitor

  • GC14308 structure
    GC14308FK866 (APO866)
    CAS: 658084-64-1
    Purity: >99.50%

    FK866 (APO866) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) (K i =0.3nM).

  • GC15274 structure
    GC15274PF-04620110
    CAS: 1109276-89-2
    Purity: >98.00%

    PF-04620110 is an orally active, selective diacylglycerol acyltransferase-1 (DGAT1) inhibitor (IC 50 = 19nM).

  • GC15442 structure
    GC15442Tipifarnib (Zarnestra)
    CAS: 192185-72-1
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC15614 structure
    GC15614A922500
    CAS: 959122-11-3
    Purity: >98.50%

    A922500 is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC 50 values of 9 and 22nM against human and mouse DGAT-1, respectively.

  • GC16129 structure
    GC16129LY 78335
    CAS: 39959-66-5
    Purity: >95.00%

    phenylethanolamine-N-methyltransferase (PNMT) inhibitor

  • GC16310 structure
    GC16310FTI 277 HCl
    CAS: 180977-34-8
    Purity: >99.00%

    FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with an IC 50 value of 0.5nM, exhibiting approximately 100-fold greater selectivity over geranylgeranyltransferase I (GGTase I).

  • GC16612 structure
    GC16612GGsTop
    CAS: 926281-37-0
    Purity: >95.00%

    GGsTop is an irreversible inhibitor of γ-glutamyl transpeptidase (GGT) (K i = 170μM).

  • GC16738 structure
    GC16738Tunicamycin Mixture
    CAS: 11089-65-9
    Purity: >95.00%

    Tunicamycin Mixture is a mixture of homologous nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT).

  • GC17046 structure
    GC17046Tris DBA
    CAS: 51364-51-3
    Purity: >98%

    N-myristoyltransferase-1 (NMT-1) inhibitor

  • GC17780 structure
    GC17780FTase Inhibitor II
    CAS: 156707-43-6
    Purity: >98.50%

    Ftase inhibitor

  • GC17921 structure
    GC17921Tolcapone
    CAS: 134308-13-7
    Purity: >98%

    A reversible COMT inhibitor

  • GC10170 structure
    GC10170LB42708
    CAS: 226929-39-1
    Purity: >98%

    Selective FTase inhibitor