FTase Inhibitor II (Synonyms: Farnesyltransferase Inhibitor II,FTI-II) |
Catalog No.GC17780
One-Click Copy Product Info
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Ftase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 156707-43-6
Sample solution is provided at 25 µL, 10mM.
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FTase Inhibitor II is a potent farnesyl transferase inhibitor.
Protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. Ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.
In vitro: Previous study found that cells were treated with FTase Inhibitor II and two GGTase inhibitors (GGTI-286 and GGTI-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μM of the drugs were added to the culture. In addition, when cells were treated with a combination of GGTI-2147 and FTase Inhibitor II, ranging from 0.1 nM to 100 μM, cell growth was not affected. Additionally, in the presence of both 50 μM FTase Inhibitor II and 50 μM GGTI-2147, the FTase and GGTase I enzyme activities were abolished [1].
In vivo: Currently, there is no animal in vivo data reported.
Clinical trial: Up to now, FTase Inhibitor II is still in the preclinical development stage.
Reference:
[1] V. Manne, C. S. Ricca, J. G. Brown, et al. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Development Research 34, 121-137 (1995).
| Cas No. | 156707-43-6 | SDF | |
| Synonyms | Farnesyltransferase Inhibitor II,FTI-II | ||
| Chemical Name | N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine | ||
| Canonical SMILES | O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1 | ||
| Formula | C15H21N3O4S2 | M.Wt | 371.5 |
| Solubility | ≤25mg/ml in water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6918 mL | 13.459 mL | 26.9179 mL |
| 5 mM | 538.4 μL | 2.6918 mL | 5.3836 mL |
| 10 mM | 269.2 μL | 1.3459 mL | 2.6918 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)