TRAP-6 (Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6) |
| Catalog No.GC11662 |
PAR1 agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 141136-83-6
Sample solution is provided at 25 µL, 10mM.
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TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].
TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].
TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats[3].
References:
[1]. Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87.
[2]. Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82(1):103-6.
[3]. Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349(2-3):237-43.
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