GLPBio

UDP-GlcNAc Disodium Salt

Catalog No.: GC33787Purity:>98.00%
COASDSData Sheet
UDP-GlcNAc Disodium Salt is produced by the hexosamine biosynthesis pathway (HBP)and acts as a precursor for several important biomolecules like glycosaminoglycans, which is an essential substrate for protein glycosylation reactions in mammals.

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UDP-GlcNAc Disodium Salt
Cas No.: 91183-98-1
1mgIn Stock
$21.00
1
5mgIn Stock
$56.00
1
10mgIn Stock
$95.00
1
25mgIn Stock
$168.00
1
100mgIn Stock
$292.00
1
500mgIn Stock
$890.00
1
1gIn Stock
$1,531.00
1
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Description

UDP-GlcNAc Disodium Salt is produced by the hexosamine biosynthesis pathway (HBP)[1]and acts as a precursor for several important biomolecules like glycosaminoglycans, which is an essential substrate for protein glycosylation reactions in mammals[2]. UDP-GlcNAc Disodium Salt is a donor substrate for glycosyltransferases, enzymes that attach sugar moieties to proteins, lipids, and nucleic acids, which is important in cellular signaling, adhesion, and immune responses[3]. UDP-GlcNAc Disodium Salt is primarily used in research on glycobiology[4] and the study of metabolic diseases, including diabetes[5] and cancer[6].

References:
[1]. Paneque A, Fortus H, Zheng J, et al. The Hexosamine Biosynthesis Pathway: Regulation and Function. Genes (Basel). 2023 Apr 18;14(4):933. doi: 10.3390/genes14040933. PMID: 37107691; PMCID: PMC10138107.
[2]. Ruegenberg S, Horn M, Pichlo C, et al. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020 Feb 4;11(1):687. doi: 10.1038/s41467-020-14524-5. PMID: 32019926; PMCID: PMC7000685.
[3]. Yang X, Qian K. Protein O-GlcNAcylation: emerging mechanisms and functions. Nat Rev Mol Cell Biol. 2017 Jul;18(7):452-465. doi: 10.1038/nrm.2017.22. Epub 2017 May 10. PMID: 28488703; PMCID: PMC5667541.
[4]. van Wijk XM, Thijssen VL, Lawrence R, et al. Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis. ACS Chem Biol. 2013 Oct 18;8(10):2331-8. doi: 10.1021/cb4004332. Epub 2013 Sep 3. PMID: 23972127; PMCID: PMC3821560.
[5]. Slawson C, Copeland RJ, Hart GW. O-GlcNAc signaling: a metabolic link between diabetes and cancer? Trends Biochem Sci. 2010 Oct;35(10):547-55. doi: 10.1016/j.tibs.2010.04.005. Epub 2010 May 11. PMID: 20466550; PMCID: PMC2949529.
[6]. Pan X, Wilson M, Mirbahai L, McConville C, Arvanitis TN, Griffin JL, Kauppinen RA, Peet AC. In vitro metabonomic study detects increases in UDP-GlcNAc and UDP-GalNAc, as early phase markers of cisplatin treatment response in brain tumor cells. J Proteome Res. 2011 Aug 5;10(8):3493-500. doi: 10.1021/pr200114v. Epub 2011 Jun 27. PMID: 21644796.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
91183-98-1
SMILES
O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)NC(C)=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+]
Molecular Formula
C17H25N3Na2O17P2
Molecular Weight
651.32
Solubility
PBS (pH 7.2): 10 mg/ml
Storage
Store at -20°C,protect from light,unstable in solution, ready to use.
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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