|Vilazodone Hydrochloride Catalog No.GC10876|
Sample solution is provided at 25 µL, 10mM.
GlpBio Products Cited In Reputable Papers
|Synonyms||EMD 68843;SB 659746A;EMD-68843;EMD68843;SB-659746A;SB659746A|
|Solubility||≥23.9 mg/mL in DMSO, <2.04 mg/mL in EtOH, <2.4 mg/mL in H2O||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.
Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD.
. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009
. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME.The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder.Curr Med Res Opin. 2012 Jan;28(1):27-39.