GLPBio

Serotonin Transporter

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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products Related to Serotonin Transporter(61)

  • GC10126 structure
    GC10126Desipramine hydrochloride
    CAS: 58-28-6
    Purity: >99.00%

    Desipramine hydrochloride is a tricyclic antidepressant.

  • GC10274 structure
    GC10274Atomoxetine HCl
    CAS: 82248-59-7
    Purity: >98.00%

    Atomoxetine HCl is a potent and selective norepinephrine uptake inhibitor, with K i values of 5, 77, and 1451nM for norepinephrine, serotonin (5-HT) and dopamine (DA).

  • GC10876 structure
    GC10876Vilazodone Hydrochloride
    CAS: 163521-08-2
    Purity: >98.00%

    An SSRI and a partial agonist of 5-HT 1A

  • GC10911 structure
    GC10911Venlafaxine hydrochloride
    CAS: 99300-78-4
    Purity: >99.50%

    Venlafaxine hydrochloride is an orally active serotonin-norepinephrine reuptake inhibitor (SNRIs) with Ki values ​​of 2480nM and 82nM for ligand binding to human NE and 5-HT transporters, respectively.

  • GC11570 structure
    GC11570Desvenlafaxine
    CAS: 93413-62-8
    Purity: >98%

    serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor

  • GC11709 structure
    GC11709Fluoxetine HCl
    CAS: 56296-78-7
    Purity: >99.50%

    Serotonin reuptake inhibitor,selective

  • GC11798 structure
    GC11798Cinchonidine
    CAS: 485-71-2
    Purity: >98.00%

    alkaloid

  • GC12055 structure
    GC12055Milnacipran HCl
    CAS: 101152-94-7
    Purity: >99.50%

    Milnacipran HCl is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.

  • GC12720 structure
    GC12720Sertraline HCl
    CAS: 79559-97-0
    Purity: >99.50%

    Sertraline HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

  • GC12885 structure
    GC12885Imipramine (hydrochloride)
    CAS: 113-52-0
    Purity: >98.00%

    serotonin and norepinephrine transporters inhibitor

  • GC13092 structure
    GC13092Fluvoxamine
    CAS: 54739-18-3
    Purity: >98%

    Fluvoxamine is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with antidepressant activity.

  • GC13161 structure
    GC13161Escitalopram
    CAS: 128196-01-0
    Purity: >98%

    Escitalopram is a highly selective serotonin reuptake inhibitor (K i =0.89nM).

  • GC13871 structure
    GC13871Duloxetine HCl
    CAS: 136434-34-9
    Purity: >99.50%

    Duloxetine HCl ((S)-Duloxetine HCl) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

  • GC14035 structure
    GC14035Citalopram hydrobromide
    CAS: 59729-32-7
    Purity: >99.50%

    5-HT uptake inhibitor

  • GC14262 structure
    GC14262Desvenlafaxine Succinate
    CAS: 386750-22-7
    Purity: >99.50%

    serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor

  • GC14330 structure
    GC14330Milnacipran
    CAS: 92623-85-3
    Purity: >98.00%

    Milnacipran is an inhibitor of the serotonin transporter (K i = 31 nM) and the monoamine transporter (K i = 8.5 nM).

  • GC14437 structure
    GC14437Vortioxetine (Lu AA21004) HBr
    CAS: 960203-27-4
    Purity: >99.50%

    Vortioxetine (Lu AA21004) HBr is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

  • GC15013 structure
    GC15013Vilazodone
    CAS: 163521-12-8
    Purity: >99.00%
  • GC15025 structure
    GC15025Fluvoxamine maleate
    CAS: 61718-82-9
    Purity: >99.50%

    Serotonin reuptake inhibitor,selective,antidepressant

  • GC15107 structure
    GC15107Clomipramine HCl
    CAS: 17321-77-6
    Purity: >99.00%

    Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM.

  • GC16312 structure
    GC16312Vortioxetine
    CAS: 508233-74-7
    Purity: >99.50%

    Vortioxetine is a multimodal antidepressant, with high affinity for recombinant human 5-HT1A (K i =15nM), 5-HT1B (K i =33nM), 5-HT3A (K i =3.7nM), 5-HT7 (K i =19nM), and noradrenergic β1 receptor (K i =46nM), and SERT (K i =1.6nM).

  • GC16797 structure
    GC16797Escitalopram Oxalate
    CAS: 219861-08-2
    Purity: >98.00%

    Escitalopram Oxalate is a highly selective serotonin reuptake inhibitor (K i =0.89nM).

  • GC17061 structure
    GC17061Dapoxetine HCl
    CAS: 129938-20-1
    Purity: >99.50%

    Selective serotonin reuptake inhibitor

  • GC17229 structure
    GC17229Paroxetine HCl
    CAS: 78246-49-8
    Purity: >99.00%

    Paroxetine HCl is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14μM.