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Home >> Signaling Pathways >> Neuroscience >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  3. GC11577 α-Methyl-5-hydroxytryptamine maleate

    α-Me-5-HT, α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin

     5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  4. GC16735 (±)-McN 5652

    5-HT uptake inhibitor

     (±)-McN 5652 Chemical Structure
  5. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  6. GC73658 (-)-5-HT2C agonist-3 (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 Chemical Structure
  7. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221 Chemical Structure
  8. GC17333 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A serotonin receptor agonist (R)-(+)-8-Hydroxy-DPAT hydrobromide Chemical Structure
  9. GC50258 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate (R)-Citalopram oxalate Chemical Structure
  10. GC67937 (R)-Mirtazapine

    (R)-Org3770; (R)-6-Azamianserin

     (R)-Mirtazapine Chemical Structure
  11. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride Chemical Structure
  12. GC63632 (Rac)-Lorcaserin (Rac)-Lorcaserin Chemical Structure
  13. GC71283 (Rac)-Rotigotine (Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. (Rac)-Rotigotine Chemical Structure
  14. GC73666 (S)-Bexicaserin (S)-Bexcaserin (compound 2) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases. (S)-Bexicaserin Chemical Structure
  15. GC67989 (S)-Mirtazapine

    (S)-Org3770; (S)-6-Azamianserin

     (S)-Mirtazapine Chemical Structure
  16. GC68410 (S)-Mirtazapine-d3

    (S)-Org3770 D3; (S)-6-Azamianserin D3

     (S)-Mirtazapine-d3 Chemical Structure
  17. GC69941 (S)-Renzapride

    (S)-BRL 24924

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  18. GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective (S)-WAY 100135 dihydrochloride Chemical Structure
  19. GC35011 (Z)-Thiothixene (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. (Z)-Thiothixene Chemical Structure
  20. GC12587 1-(1-Naphthyl) piperazine (hydrochloride)

    1-NP

     ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride) Chemical Structure
  21. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    3-Chlorophenylpiperazine,meta-Chlorophenylpiperazine,1-(m-Chlorophenyl)piperazine,3-CPP,mCPP

    5-HT2C/2B receptor agonist/partial agonist

     1-(3-Chlorophenyl)piperazine (hydrochloride) Chemical Structure
  22. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin Chemical Structure
  23. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride Chemical Structure
  24. GC60017 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway. 2'-O-Methylisoliquiritigenin Chemical Structure
  25. GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT Chemical Structure
  26. GC11176 2-Methyl-5-hydroxytryptamine hydrochloride

    2-Methyl-5-hydroxytryptamine hydrochloride; 2-Methylserotonin hydrochloride; 2-Me-HT hydrochloride

     2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-hydroxytryptamine hydrochloride Chemical Structure
  27. GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor 2-[1-(4-Piperonyl)piperazinyl]benzothiazole Chemical Structure
  28. GC14343 3,4-dihydro Naratriptan

    Naratriptan Impurity B

     selective serotonin 5-HT1B agonist 3,4-dihydro Naratriptan Chemical Structure
  29. GC15569 3-AQC 5-HT3 antagonist 3-AQC Chemical Structure
  30. GC60499 3-Hydroxy agomelatine 3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine Chemical Structure
  31. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3 Chemical Structure
  32. GC62799 4,4-Diphenylbutylamine hydrochloride 4,4-Diphenylbutylamine shows affinity for the 5-HT2A and H1 receptors with Kis of 2589 and 1670 nM, respectively. 4,4-Diphenylbutylamine hydrochloride Chemical Structure
  33. GC16040 4F 4PP oxalate 5-HT2A antagonist 4F 4PP oxalate Chemical Structure
  34. GC14814 5-Carboxamidotryptamine maleate

    5-CT maleate

     5-HT1 agonist 5-Carboxamidotryptamine maleate Chemical Structure
  35. GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. 5-HT1A modulator 1 Chemical Structure
  36. GC60028 5-HT1A modulator 2 hydrochloride 5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT, is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding. 5-HT1A modulator 2 hydrochloride Chemical Structure
  37. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1 Chemical Structure
  38. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 Chemical Structure
  39. GC71279 5-HT2A receptor agonist-3

    5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM, and with 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor.

     5-HT2A receptor agonist-3 Chemical Structure
  40. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 Chemical Structure
  41. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1 Chemical Structure
  42. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2 Chemical Structure
  43. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5 Chemical Structure
  44. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1 Chemical Structure
  45. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1 Chemical Structure
  46. GC31144 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. 5-HT7 agonist 1 Chemical Structure
  47. GC14940 5-Methoxytryptamine 5-Methoxytryptamine Chemical Structure
  48. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  49. GC17477 5-Nonyloxytryptamine oxalate 5-HT1B agonist 5-Nonyloxytryptamine oxalate Chemical Structure
  50. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1 Chemical Structure
  51. GC14000 6-fluoro-DL-Tryptophan

    DL-6-Fluorotryptophan,NSC 9364

     6-fluoro-DL-Tryptophan is a potent, competitive inhibitor of tryptophan hydroxylase. 6-fluoro-DL-Tryptophan Chemical Structure
  52. GC14966 8-Hydroxy-DPAT hydrobromide

    8-OH-DPAT

     5-HT1A agonist 8-Hydroxy-DPAT hydrobromide Chemical Structure
  53. GC12427 8-Hydroxy-PIPAT oxalate 5-HT1A receptor agonist 8-Hydroxy-PIPAT oxalate Chemical Structure
  54. GC30888 8-OH-DPAT (8-Hydroxy-DPAT)

    8-Hydroxy-DPAT

     8-OH-DPAT, at a pIC50 of 8.19, exhibits robust and specific agonistic activity on 5-HT1A receptors, indicating high selectivity. 8-OH-DPAT (8-Hydroxy-DPAT) Chemical Structure
  55. GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. Abaperidone Chemical Structure
  56. GC35252 Adoprazine Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine Chemical Structure
  57. GC17981 Agomelatine

    S20098

     Agomelatine is a melatonin (MT) receptor agonist with Ki values of 0.1 nM and 0.12 nM for MT1 and MT2, respectively. Agomelatine is also a 5-hydroxytryptamine (5-HT) receptor antagonist with Ki values of 631 nM and 660 nM for 5-HT2C and 5-HT2B respectively. Agomelatine Chemical Structure
  58. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride Chemical Structure
  59. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid Chemical Structure
  60. GC11556 AL 34662

    AL 34497

     potent 5-HT2 receptor agonist AL 34662 Chemical Structure
  61. GC15153 Almotriptan Malate

    PNU 180638E

     5-HT1B/1D-receptor agonist Almotriptan Malate Chemical Structure
  62. GC31054 Alniditan (Alnitidan)

    Alnitidan

     Alniditan (Alnitidan) (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan (Alnitidan) Chemical Structure
  63. GC62417 Alniditan dihydrochloride Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride Chemical Structure
  64. GC13654 Alosetron A 5-HT3 receptor antagonist Alosetron Chemical Structure
  65. GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron ((Z)-2-butenedioate) Chemical Structure
  66. GC35302 Alosetron (Hydrochloride(1:X)) Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Hydrochloride(1:X)) Chemical Structure
  67. GC35303 Alosetron D3 Hydrochloride

    GR-68755C D3

     Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist. Alosetron D3 Hydrochloride Chemical Structure
  68. GC11166 Alosetron Hydrochloride

    GR 68755

     A 5-HT3 receptor antagonist Alosetron Hydrochloride Chemical Structure
  69. GC64265 Alosetron-13C,d3

    GR 68755-13C,d3; GR 68755X-13C,d3

     Alosetron-13C,d3 Chemical Structure
  70. GC32905 Alprenolol ((RS)-Alprenolol)

    (±)-Alprenolol, dl-Alprenolol, (RS)-Alprenolol

     Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol ((RS)-Alprenolol) Chemical Structure
  71. GC14105 Alprenolol hydrochloride β-adrenoceptor and 5-HT1A receptor antagonist. Alprenolol hydrochloride Chemical Structure
  72. GC14030 Altanserin hydrochloride 5-HT2A receptor antagonist Altanserin hydrochloride Chemical Structure
  73. GC10891 Alverine Citrate

    NSC 35459

     Drug used for functional gastrointestinal disorders Alverine Citrate Chemical Structure
  74. GC13723 Amitriptyline HCl

    NIH 10794, Ro 4-1575

     Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl Chemical Structure
  75. GC70513 Amperozide Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide Chemical Structure
  76. GC14008 Anpirtoline hydrochloride 5-HT1B receptor agonist Anpirtoline hydrochloride Chemical Structure
  77. GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. Ansofaxine hydrochloride (LY03005) Chemical Structure
  78. GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. AP521 Chemical Structure
  79. GC31291 AR-A 2 (AR-A 000002)

    AR-A 000002

     AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. AR-A 2 (AR-A 000002) Chemical Structure
  80. GC10117 Aripiprazole

    OPC 31, OPC 14597

     5-HT receptor partial agonist Aripiprazole Chemical Structure
  81. GC35386 Aripiprazole D8

    OPC-14597 D8

     Aripiprazole D8 Chemical Structure
  82. GC68687 Aripiprazole-d8

    Aripiprazole-d8 is the deuterated form of Aripiprazole.

     Aripiprazole-d8 Chemical Structure
  83. GC17525 AS 19 Potent 5-HT7 agonist AS 19 Chemical Structure
  84. GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor Asenapine Chemical Structure
  85. GC14518 Asenapine hydrochloride Asenapine hydrochloride Chemical Structure
  86. GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Asenapine maleate Chemical Structure
  87. GC16807 AT 1015 Long-acting 5-HT2A antagonist AT 1015 Chemical Structure
  88. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492 Chemical Structure
  89. GC15687 Azasetron HCl

    Y-25130

     Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl Chemical Structure
  90. GC14491 B-HT 920 A potent agonist of D2 receptors B-HT 920 Chemical Structure
  91. GC31113 Befiradol (NLX-112) Befiradol (NLX-112) (NLX-112) is a selective 5-HT1A receptor agonist. Befiradol (NLX-112) Chemical Structure
  92. GC60630 Befiradol hydrochloride

    NLX-112 hydrochloride; F 13640 hydrochloride

     Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-HT1A receptor agonist. Befiradol hydrochloride Chemical Structure
  93. GC34304 Befiradol hydrochloride (NLX-112 (hydrochloride)) Befiradol hydrochloride (NLX-112 (hydrochloride)) Chemical Structure
  94. GC15092 BGC 20-761 5-HT6 antagonist,selective and high affinity BGC 20-761 Chemical Structure
  95. GC12541 Bilobalide A neuroprotective natural product Bilobalide Chemical Structure
  96. GC14925 BIMU 8 5-HT4 agonist BIMU 8 Chemical Structure
  97. GC14160 Blonanserin

    AD5423, Lonasen

     Atypical antipsychotic Blonanserin Chemical Structure
  98. GC10848 BMY 7378 BMY 7378 is a selective antagonist of α1D-adrenergic receptor (α1D-AR) with a pki value of 8.89. It is also a mixed agonist and antagonist of serotonin 1A receptor (5-HT1A R). BMY 7378 Chemical Structure
  99. GC15311 BP 554 maleate Selective 5-HT1A agonist BP 554 maleate Chemical Structure
  100. GC11186 Brexpiprazole

    OPC 34712

     5-HT2A, α1B-, and α2C-adrenergic receptors antagonist Brexpiprazole Chemical Structure
  101. GC60662 Brexpiprazole S-oxide

    Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4).

     Brexpiprazole S-oxide Chemical Structure

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