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Xanthine Oxidase

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Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.

Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.

Products Related to Xanthine Oxidase(20)

  • GC10827 structure
    GC10827Oxipurinol
    CAS: 2465-59-0
    Purity: >98.00%

    Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase.

  • GC14930 structure
    GC14930Benzbromarone
    CAS: 3562-84-3
    Purity: >99.50%

    TMEM16A/B calcium-activated chloride channel (CaCC) blocker

  • GC15322 structure
    GC15322Allopurinol
    CAS: 315-30-0
    Purity: >98.00%

    Allopurinol is a pyrazolopyrimidine xanthine oxidase inhibitor with IC 50 of 7.82±0.12μM.

  • GC16127 structure
    GC16127Topiroxostat
    CAS: 577778-58-6
    Purity: >98.00%

    Xanthine oxidoreductase (XOR) inhibitor

  • GC16319 structure
    GC16319Febuxostat
    CAS: 144060-53-7
    Purity: >99.50%

    Febuxostat is a potent, selective, non-purine inhibitor of xanthine oxidase (XO) and xanthine dehydrogenase (XDH), with an inhibition constant (Ki) of 0.6nM against XO.

  • GC17025 structure
    GC17025Oxonic acid potassium salt
    CAS: 2207-75-2
    Purity: >98.00%

    Oxonic acid potassium salt selectively and competitively inhibits the activity of uricase, effectively elevating uric acid levels in vivo. Oxonic acid potassium salt inhibits the phosphorylation of 5-fluorouracil (5-FU) to 5-fluorouridine-5'-monophosphate.

  • GC33813 structure
    GC33813Xanthine oxidase-IN-1
    CAS: 1071970-13-2
    Purity: >98%

    Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.

  • GC36036 structure
    GC36036Febuxostat D9
    CAS: 1246819-50-0
    Purity: >98%

    Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

  • GC36903 structure
    GC36903Phytic acid dodecasodium salt hydrate
    CAS: 123408-98-0
    Purity: >98.00%

    Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains.

  • GC38116 structure
    GC38116Purpurogallin
    CAS: 569-77-7
    Purity: >98.00%

    A phenol

  • GC39050 structure
    GC39050Prudomestin
    CAS: 3443-28-5
    Purity: >98%

    Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6??M).

  • GC41531 structure
    GC41531Anacardic Acid Triene
    CAS: 103904-73-0
    Purity: >98.00%

    Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid.

  • GC42578 structure
    GC425786-Formylpterin
    CAS: 712-30-1
    Purity: >98.00%

    Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

  • GC52049 structure
    GC52049Myricetin 3-galactoside
    CAS: 15648-86-9
    Purity: >98.00%

    Myricetin 3-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical.

  • GC64122 structure
    GC64122Tigulixostat
    CAS: 1287766-55-5
    Purity: >98%

    Tigulixostat (LC350189) is an orally active, non-purine selective xanthine oxidase inhibitor.

  • GC72063 structure
    GC720637,8,3′,4′-Tetrahydroxyflavone
    CAS: 3440-24-2
    Purity: >99.00%

    7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 value of 10.488 µM.

  • GC72074 structure
    GC72074Broussoflavonol F
    CAS: 162558-94-3
    Purity: >98.00%

    Broussoflavonol F possess xanthine oxidase inhibitory activity.

  • GC79625 structure
    GC79625Febuxostat 67M-1
    CAS: 887945-96-2
    Purity: >95.00%

    Febuxostat 67M-1 is an active metabolite of Febuxostat.

  • GN10158 structure
    GN10158Baicalein
    CAS: 491-67-8
    Purity: >98.00%

    Baicalein (5,6,7-trihydroxyflavone) is a flavonoid compound with multiple biological activities. It is a xanthine oxidase inhibitor with an IC 50 value of 3.12μM.

  • GN10554 structure
    GN10554Phytic acid
    CAS: 83-86-3
    Purity: >98%

    Phytic acid is an antinutrient found naturally in legume seeds.