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PI3K/Akt/mTOR Signaling

Research Areas

Products Related to PI3K/Akt/mTOR Signaling(719)

  • GC73992 structure
    GC73992KTC1101
    CAS: 2764833-47-6
    Purity: >98.00%

    KTC1101 هو مثبط PI3K نشط عن طريق الفم.

  • GC74012 structure
    GC74012MTX-531
    CAS: 2791417-66-6
    Purity: >99.00%

    MTX-531 هو دواء عن طريق الفم يثبط EGFR (مع IC50 من 14.7nM) و PI3K (مع قيم IC50 من 6.4، 233، 8.3 و 1.1nM ل PI3Kα، PI3Kβ، و PI3Kγ و PI3Kδ على التوالي)، وله تأثيرات مضادة للورم.

  • GC74025 structure
    GC74025PIKfyve-IN-3
    Purity: >99.00%

    PIKfyve-IN-3 (مركب L22) لديه تفاعل ملحوظ مع كيناز بيكفيف مع قيمة Kd من 0.47 نانومتر.

  • GC74026 structure
    GC74026DNA-PK-IN-12
    CAS: 2792146-91-7
    Purity: >99.00%

    DNA-PK-IN-12 (مركب 31t) هو مثبط DNA-PK نشط عن طريق الفم مع IC50 من 0.1 نانومتر.

  • GC74029 structure
    GC74029ASCT2-IN-1
    CAS: 3032651-18-3
    Purity: >98.00%

    ASCT2-IN-1 (مركب 20k) هو مثبط ASCT2 مع قيم IC50 من 5.6 ميكرومتر و 3.5 ميكرومتر في الخلايا A549 و HEK293، على التوالي.

  • GC74030 structure
    GC74030ASCT2-IN-2
    Purity: >99.00%

    ASCT2-IN-2 (مركب 25e) هو مثبط ASCT2 مع IC50 من 5.14 ميكرومتر.

  • GC74044 structure
    GC74044ARM165
    Purity: >99.00%

    ARM165 هو جزيء غير وظيفي.

  • GC74094 structure
    GC74094Leniolisib-d5
    Purity: >98.00%

    Leniolisib-d5 هو deuterated المسمى Leniolisib.

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    Purity: >98.00%

    (R)-(+)-O-Demethylbuchenavianine هو مثبط للكيناز المعتمد على السايكلين CDK.

  • GC74689 structure
    GC74689WRX606
    CAS: 899937-47-4
    Purity: >95.00%

    WRX606 هو مثبط لمركب mTOR 1 (mTORC1).

  • GC78798 structure
    GC78798NN3201
    Purity: >99.00%

    NN3201 is a c-Kit -targeting antibody-drug conjugate ( ADC ) with high affinity ( K D = 0.19 pM).

  • GC78965 structure
    GC78965ACT001 hydrochloride
    CAS: 1403357-80-1
    Purity: >98.00%

    ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent.

  • GC78981 structure
    GC78981HBS-101
    Purity: >99.50%

    HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor ( K D = 38.4 nM).

  • GC79003 structure
    GC79003WCY-8-67 TFA
    Purity: >99.00%

    WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

  • GC79077 structure
    GC79077DDO-6600
    CAS: 2640292-37-9
    Purity: >98.00%

    DDO-6600 is a covalent Hsp90 inhibitor.

  • GC79104 structure
    GC79104(Rac)-Chem-0199
    CAS: 122981-77-5
    Purity: >99.50%

    (Rac)-Chem-0199 is the racemic mixture of Chem-0199.

  • GC79108 structure
    GC79108AP4-43
    Purity: >99.50%

    AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC79117 structure
    GC791178012–3246
    CAS: 421586-94-9
    Purity: >99.50%

    8012-3246 is a selective PLK2 inhibitor with an IC 50 of 774.5 nM.

  • GC79141 structure
    GC79141T7 Peptide TFA
    Purity: >98.00%

    T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a K d of 10 nM for human transferrin receptor.

  • GC79175 structure
    GC79175AMPK activator 19
    CAS: 1273323-44-6
    Purity: >98%

    AMPK activator 19 (Compound 57), alkene oxindole derivative, is an AMPK activator.

  • GC79176 structure
    GC79176ARUK2010489
    Purity: >96.50%

    ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC 50 of 8.7.

  • GC79177 structure
    GC79177AMPK activator 18
    CAS: 1364692-88-5
    Purity: >98.00%

    AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform.

  • GC79228 structure
    GC79228Peptide R54 acetate
    Purity: >99.50%

    Peptide R54 acetate (Pep R54 acetate) is a CXCR4 antagonist.