GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(358)

  • GC73968 structure
    GC73968Pim-1 kinase inhibitor 8
    CAS: 916038-47-6
    Purity: >99.00%

    Pim-1 kinase inhibitor 8 (مركب 12) هو مثبط قوي من بيم -1 كيناز مع IC50 من 14.3 نانومتر.

  • GC74116 structure
    GC74116Pyk2-IN-2
    CAS: 1271418-15-5
    Purity: >98.00%

    Pyk2-IN-2 (المركب 13j) هو مثبط Pyk2 مع IC50 من كيناز FAK من 0.608 ميكرومتر.

  • GC74190 structure
    GC74190Hydrochlorothiazide-13C6
    CAS: 1261396-79-5
    Purity: >99.00%

    Hydrochlorothiazide-13C6 هو 13C المسمى دروكلوروثيازيد.

  • GC74326 structure
    GC74326MPSD TFA
    Purity: >98.00%

    MPSD TFA (MarCKS-ED TFA) هو شكل ملح TFA من MPSD.

  • GC74417 structure
    GC74417PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA
    Purity: >98.00%

    PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA هو ببتيد اصطناعي يمكن استخدامه لدراسة آلية عمل PKCθ.

  • GC74419 structure
    GC74419N-myristoyl-RKRTLRRL
    CAS: 152246-40-7
    Purity: >99.00%

    N-myristoyl-RKRTLRRL يمنع ربط ركائز PKC.

  • GC74516 structure
    GC74516Bintrafusp alfa
    CAS: 1918149-01-5
    Purity: >97.00%

    Bintrafusp alfa (M 7824) هو أول بروتين اندماج ثنائي الوظائف في الفئة يتألف من المجال خارج الخلية من TGF-βRII المندمج إلى IgG1 mAb الإنسان منع ربيطة موت الخلية المبرمجة.

  • GC74573 structure
    GC74573Livmoniplimab
    CAS: 2412004-88-5
    Purity: >99.00%

    Livmoniplimab (ABBV-151) هو جسم مضاد وحيد النسل ضد GARP/TGF-β1 الذي يمكن أن يمنع إطلاق نشط TGF-β1.

  • GC74617 structure
    GC74617SHR-1701
    CAS: 2891860-17-4
    Purity: >99.00%

    SHR-1701 (Retlirafusp alfa) هو بروتين اندماج ثنائي الوظائف يستهدف PD-L1 و TGF-β لأبحاث السرطان.

  • GC79115 structure
    GC79115ROCK2-IN-12
    CAS: 3086603-12-2
    Purity: >98.00%

    ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC 50 of 7.0 nM for ROCK2 over ROCK1.

  • GC79116 structure
    GC79116NRL-1049 dihydrochloride
    CAS: 1973494-17-5
    Purity: >99.00%

    NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 ( ROCK2 ) inhibitor with an IC 50 of 0.59 μM.

  • GC79186 structure
    GC79186(1S,4R)-CC-90005
    Purity: >99.50%

    (1S,4R)-CC-90005 is the (1S,4R)-enantiomer of CC-90005.

  • GC79187 structure
    GC79187TAT-Epsilon-V1-2 TFA
    Purity: >99.50%

    TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor.

  • GC79188 structure
    GC79188TAS1440
    CAS: 2098585-77-2
    Purity: >98.00%

    TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC 50 of 4.8 nM.

  • GC79707 structure
    GC79707ST1072
    CAS: 1402703-50-7
    Purity: >98%

    ST1072 is an inhibitor of CerS4 and CerS6.

  • GC80859 structure
    GC80859RepSox-d 5
    Purity: >98%

    RepSox -d 5 (E-616452-d 5 ) is the deuterium labeled RepSox.

  • GC81302 structure
    GC81302Asciminib-NH2
    CAS: 3106065-83-9
    Purity: >97.00%

    Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As [1] .

  • GC81341 structure
    GC81341IKVAVC acetate
    Purity: >98.00%

    IKVAVC acetate is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus.

  • GC81342 structure
    GC81342CMF9
    Purity: >98.50%

    CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction.

  • GC81350 structure
    GC81350THR-123 TFA
    Purity: >99.50%

    THR-123 TFA is an orally active ALK3 peptide agonist.

  • GC81351 structure
    GC81351Endotrophin (Mus musculus) TFA
    Purity: >96.50%

    Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice.

  • GC81352 structure
    GC81352Anti-ALK7 Antibody
    Purity: >97.50%

    Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7.

  • GC81353 structure
    GC81353PF-07868489
    Purity: >99.00%

    PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.