Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.
CHM 1
Catalog No.: GC17969Purity:>98%Synonyms: NSC 656158
An inhibitor of tubulin polymerization
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 154554-41-3
1mgIn Stock
$33.00
1
5mgIn Stock
$83.00
1
10mgIn Stock
$133.00
1
25mgIn Stock
$224.00
1
50mgIn Stock
$328.00
1
100mgIn Stock
$469.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $33.00 | In Stock | 1 | |
| 5mg | $83.00 | In Stock | 1 | |
| 10mg | $133.00 | In Stock | 1 | |
| 25mg | $224.00 | In Stock | 1 | |
| 50mg | $328.00 | In Stock | 1 | |
| 100mg | $469.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
154554-41-3
Synonyms
NSC 656158
Chemical Name
6-(2-fluorophenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
SMILES
C1OC2=C(O1)C=C3C(=C2)C(=O)C=C(N3)C4=CC=CC=C4F
Molecular Formula
C16H10FNO3
Molecular Weight
283.25
Solubility
<7.08mg/ml in Water
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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