GLPBio

Angiogenesis

Research Areas

Products Related to Angiogenesis(378)

  • GC43514 structure
    GC43514D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)
    Purity: >98.00%

    Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.

  • GC43515 structure
    GC43515D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)
    Purity: >98.00%

    The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

  • GC43727 structure
    GC43727Ganglioside GD1a mixture (sodium salt)
    CAS: 12707-58-3
    Purity: >98.00%

    Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.

  • GC43732 structure
    GC43732Ganglioside GM3 Mixture (sodium salt)
    CAS: 54827-14-4
    Purity: >98.00%

    Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.

  • GC43803 structure
    GC43803HA-1077 (hydrochloride)
    CAS: 203911-27-7
    Purity: >98.00%

    Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM fÜr ROCK2 bzw. PKA, PKC, PKG. HA-1077 (Hydrochlorid) ist auch ein potenter Ca2+-Kanalantagonist und Vasodilatator.

  • GC44290 structure
    GC44290NAADP (sodium salt)
    Purity: >95.00%

    Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.

  • GC44358 structure
    GC44358Nebivolol O-β-D-Glucuronide
    Purity: >95.00%

    Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

  • GC44465 structure
    GC44465NSC 12
    CAS: 102586-30-1
    Purity: >98.00%

    NSC 12 ist eine extrazellulÄre Falle des Fibroblasten-Wachstumsfaktors 2 (FGF2), der FGF2 bindet und seine Wechselwirkung mit FGFR1 stÖrt. NSC 12 hemmt die Proliferation verschiedener FGF-abhÄngiger Tumorzellen sowohl in vitro als auch in vivo ohne systemische toxische Wirkungen.

  • GC44475 structure
    GC44475NVP-BEZ235 (hydrochloride)
    CAS: 2319647-83-9
    Purity: >98.00%

    NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies.

  • GC44584 structure
    GC44584PD 168368
    CAS: 204066-82-0
    Purity: >95.00%

    PD 168368 ist ein potenter, kompetitiver und selektiver Neuromedin-B-Rezeptor (NMB-R)-Antagonist mit einem Ki von 15-45 nM. PD 168368 ist ein Antagonist des Neuromedin-B-Rezeptors (NMBR; IC50=96 nM)/Gastrin-Releasing-Peptid-Rezeptors (GRPR IC50=3500 nM). PD 168368 ist auch ein gemischter FPR1/FPR2/FPR3-Agonist mit EC50-Werten von 0,57, 0,24 bzw. 2,7 nM.

  • GC44800 structure
    GC44800Quininib
    CAS: 143816-42-6
    Purity: >98%

    A CysLT 1 and CysLT 2 receptor antagonist

  • GC44956 structure
    GC44956Streptochlorin
    CAS: 120191-51-7
    Purity: >98.00%

    Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp.

  • GC44966 structure
    GC44966Sucrose octasulfate (potassium salt)
    CAS: 73264-44-5
    Purity: >95.00%

    Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.

  • GC45054 structure
    GC45054Tie2 Inhibitor 7
    CAS: 1020412-97-8
    Purity: >95.00%

    Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..

  • GC45269 structure
    GC45269(±)10(11)-DiHDPA
    CAS: 1345275-22-0
    Purity: >98.00%

    (±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid.

  • GC45677 structure
    GC45677Anlotinib (hydrochloride)
    CAS: 1058157-76-8
    Purity: >98.00%

    A neuropeptide with diverse biological activities

  • GC45688 structure
    GC45688STX140
    CAS: 401600-86-0
    Purity: >98.00%

    An estrogen sulfamate

  • GC45767 structure
    GC45767Dovitinib-d8
    CAS: 1246819-84-0
    Purity: >99.00%

    Dovitinib-D8 (CHIR-258-D8) ist das mit Deuterium bezeichnete Dovitinib. Dovitinib (CHIR-258) ist ein Multi-Targeting-Tyrosinkinase-Inhibitor mit IC50-Werten von 1, 2, 8/9, 10/13/8, 27/210 nM fÜr FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/ VEGFR3 bzw. PDGFRα/PDGFRβ.

  • GC45769 structure
    GC45769Vandetanib-d6
    CAS: 1174683-49-8
    Purity: >99.00%

    Vandetanib-d6 (ZD6474-d6) ist das als Vandetanib bezeichnete Deuterium. Vandetanib (D6474) ist ein potenter, oral aktiver Inhibitor der VEGFR2/KDR-Tyrosinkinase-AktivitÄt (IC50=40 nM). Vandetanib hat auch AktivitÄt gegenÜber der Tyrosinkinase-AktivitÄt von VEGFR3/FLT4 (IC50 = 110 nM) und EGFR/HER1 (IC50 = 500 nM).

  • GC45798 structure
    GC45798Rhein-13C4
    CAS: 1189928-10-6
    Purity: >95.00%

    An internal standard for the quantification of rhein

  • GC45880 structure
    GC45880Cimetidine-d3
    CAS: 1185237-29-9
    Purity: >99.00%

    An internal standard for the quantification of cimetidine

  • GC45922 structure
    GC45922(±)11(12)-EET-d11 methyl ester
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC46304 structure
    GC46304(±)-Nebivolol-d4 (hydrochloride)
    CAS: 2701283-32-9
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC46474 structure
    GC4647418-Deoxyherboxidiene
    CAS: 1200128-66-0
    Purity: >70.00%

    18-Desoxyherboxidien (RQN-18690A) ist ein potenter Angiogenese-Inhibitor.