Cardiovascular

5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods.

The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate.

Levonordefrin, eine gebrÄuchliche Alternative zu Levoepinephrin als Vasokonstriktor in zahnÄrztlichen LokalanÄsthesieprÄparaten, wird Üblicherweise in fÜnffach hÖheren Konzentrationen eingesetzt.

(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.

Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism.

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.

Propranolol, one of the first β-blockers used in cardiovascular medicine, inhibits β1-, β2-, and β3-adrenergic receptors with log KD values of -8.16, -9.08, and -6.93, respectively.

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.

15-deoxy-δ12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-δ12,14-PGJ2.

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures.

16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2.

15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2.

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.

15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2.

Pinane thromboxane A2 (PTA2) is a stable analog of TXA2.

N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan.

(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors.

ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.

11-deoxy PGF1α is a synthetic analog of PGF1α.

11-deoxy PGF1β is a synthetic analog of PGF1β.

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.