Cardiovascular

Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1 that is selective for CB1 (Ki = 178 nM; Kb = 66.6 nM) over CB2, with no activity at CB2 receptors at concentrations up to 10 μM.

Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II by angiotensin-converting enzyme (ACE).

Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.

Angiotensinogen (1-13) is a synthetic peptide precursor of angiotensin I that corresponds to amino acids 1-13 of endogenous human angiotensinogen.

Angiotensinogen (1-14), also known as tetradecapeptide (TDP), is a synthetic peptide precursor of angiotensin I that corresponds to amino acids 1-14 of endogenous human angiotensinogen.

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria.

Atpenin A5 ist ein potenter und hochspezifischer Komplex-II-Inhibitor (IC50 ~10 nM) und ein wirksamer mKATP-Kanal-Agonist und kardioprotektives Mittel.

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.

Atrial natriuretic peptide (ANP) (3-28) is a synthetic and truncated form of ANP, which is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.

Benazeprilat ist ein oral wirksamer Wirkstoff und der aktive Metabolit von Benazepril, einem Carboxyl-haltigen ACE-Hemmer mit blutdrucksenkender Wirkung.

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function.

Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 produced by vascular smooth muscle and endothelium.

Bis(methylthio)gliotoxin ist ein stabilerer und zuverlÄssigerer Marker fÜr invasive Aspergillose als Gliotoxin und fÜr die Verwendung in der Diagnose geeignet.

Bopindolol ((±)-Bopindolol)malonat ist ein oral aktiver Antagonist von β-Adrenozeptoren (ARs) mit partieller agonistischer AktivitÄt.

Brain natriuretic peptide (BNP) (1-32) is an endogenous peptide that has cardiovascular functions and belongs to the family of natriuretic peptides, which includes atrial natriuretic peptide and C-type natriuretic peptide.

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate polymorphonuclear leukocytes.

C2 Ceramide (d14:1/2:0) ist eine Zusammensetzung zur Diagnose von Krankheiten, die mit einer Überexpression von Cyclooxygenase 2 (COX2) verbunden sind. C2-Ceramid (d14:1/2:0) zeigt eine starke BindungsaktivitÄt an das COX2-Protein (aus dem Patent WO2019235824A1 entnommen).

Campestanol ist ein Phytosterin, das in pflanzlicher Nahrung vorkommt.

Captoprildisulfid ist ein Metabolit von Captopril mit blutdrucksenkender Wirkung.

Caspase-9 inhibitor III is an inhibitor of caspase-9 with cardioprotective effects.

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.

TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2).

Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism.