Cardiovascular

12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).

13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.

15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life.

1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position.

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.

2-ChlorpalmitinsÄure, ein entzÜndlicher Lipidmediator, stÖrt die Proteinpalmitylierung, induziert ER-Stressmarker, reduziert den ER-ATP-Gehalt und aktiviert die Transkription und Sekretion von IL-6 sowie IL-8.2-ChlorpalmitinsÄure stÖrt die Mitochondrien Membranpotential und induziert die Procaspase-3- und PARP-Spaltung. 2-ChlorpalmitinsÄure kann die Blut-Hirn-Schranke (BBB) Überwinden und beeintrÄchtigt ER- und Mitochondrienfunktionen in der Endothelzelllinie hCMEC/D3 des menschlichen Gehirns.

2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0).

2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.

4-AminobenzoesÄurehydrazid ist ein irreversibler MPO-Myeloperoxidase-Hemmer mit einem IC50-Wert von 0,3 μM.

4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.

4-hydroxy Nebivolol is a major metabolite of nebivolol.

4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.

5-chloro Hydrochlorothiazide is a derivative of hydrochlorothiazide, which is a diuretic and antihypertensive agent that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.

5-methyl-2-HOBA is an isoketal scavenger.

9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

Acecainide is an active metabolite of the class III antiarrhythmic procainamide.

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52).

Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen, as well as in the duodenum and submandibular glands.

Adrenomedullin (1-52) is a peptide with diverse biological activities.

Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds.