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JAK

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Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

Products Related to JAK(169)

  • GC71475 structure
    GC71475JAK1-IN-13
    CAS: 2778330-90-6
    Purity: >98.00%

    JAK1-IN-13 (Verbindung 36b) ist ein oral aktiver, potenter und hochselektiver Inhibitor von JAK1 mit einem IC50 von 0,044 nM.

  • GC71575 structure
    GC71575Deuruxolitinib
    CAS: 1513883-39-0
    Purity: >99.00%

    Deuruxolitinib, ein deuteriertes Ruxolitinib moduliert die Aktivität von JAK1/JAK2.

  • GC72769 structure
    GC72769(1R)-AZD-1480
    CAS: 935666-99-2
    Purity: >97.00%

    (1R)-AZD-1480 ist das 1R chirale Isomer von AZD-1480, einem ATP-kompetitiven JAK1- und JAK2-Inhibitor.

  • GC72815 structure
    GC72815Itacnosertib (hydrocholide)
    CAS: 2409543-84-4
    Purity: >99.00%

    Itacnosertib (hydrocholide) ist ein Inhibitor von JAK2, ACVR1 ALK2 und ALK5.

  • GC73139 structure
    GC73139SJ1008030 formic
    Purity: >97.00%

    SJ1008030 formic ist ein JAK2 PROTAC, das JAK2 selektiv abbaut.

  • GC73148 structure
    GC73148JAK-IN-21
    CAS: 2445499-20-5
    Purity: >99.00%

    JAK-IN-21 (Beispiel 4) ist ein selektiver und potenter JAK-Inhibitor mit IC50s von 1.73, 2.04, 109 und 62.9 nM gegen JAK1, JAK2, J2V617F und TYK2.

  • GC73369 structure
    GC73369SJ988497
    CAS: 2595365-41-4
    Purity: >98.00%

    SJ988497 ist ein PROTAC JAK2-Abbauer.

  • GC73456 structure
    GC73456JAK1-IN-11
    CAS: 2427608-43-1
    Purity: >98.00%

    JAK1-IN-11 (Verbindung 11) ist ein potenter Hemmer von JAK, mit IC50s von 0.02 nM (JAK1) und 0.44 nM (JAK2).

  • GC73475 structure
    GC73475JAK-IN-26
    CAS: 2417134-93-9
    Purity: >98.00%

    JAK-IN-26 (Verbindung 2) ist ein oral aktiver JAK-Inhibitor mit guten pharmakokinetischen Eigenschaften.

  • GC73600 structure
    GC73600JAK3-IN-14
    CAS: 454234-24-3
    Purity: >99.00%

    JAK3-IN-14 (Verbindung 1) ist ein potenter JAK3-Inhibitor mit IC50-Werten von 38 und 600 nM für JAK3 bzw. JAK2.

  • GC73627 structure
    GC73627HDAC/JAK/BRD4-IN-1
    CAS: 2755325-84-7
    Purity: >95.00%

    HDAC/JAK/BRD4-IN-1(Verbindung 25ap) ist ein starker HDAC/JAK/BRD4 Triple Inhibitor.

  • GC79003 structure
    GC79003WCY-8-67 TFA
    Purity: >99.00%

    WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

  • GC79070 structure
    GC79070WWQ-03-012
    CAS: 3076807-15-0
    Purity: >98.00%

    WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM.

  • GC79181 structure
    GC79181RAI-20
    CAS: 2549180-90-5
    Purity: >98.50%

    RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor ( IC 50 =15.1 and 22.7 nM).

  • GC80468 structure
    GC80468Peficitinib-d 3
    Purity: >98%

    Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.

  • GC80946 structure
    GC80946PROTAC JAK1/2 degrader-1
    Purity: >99.00%

    PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.

  • GC80947 structure
    GC80947JAK1/2 ligand 1
    CAS: 1026028-96-5
    Purity: >99.50%

    JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

  • GC91059 structure
    GC91059LCC-12 (formate)
    Purity: >98.00%

    Ein Kupfer (II)-Chelator und Derivat von Metformin.

  • GC91148 structure
    GC91148JAK Inhibitor 31
    CAS: 2891469-99-9
    Purity: >98.00%

    Ein JAK2-Inhibitor

  • GC91506 structure
    GC91506Bayer 18
    CAS: 1251752-12-1
    Purity: >98.00%

    Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).

  • GC91689 structure
    GC91689TG46
    CAS: 936091-15-5
    Purity: >98.00%

    TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

  • GN10442 structure
    GN10442Curculigoside
    CAS: 85643-19-2
    Purity: >99.50%
  • GN10584 structure
    GN10584Ginsenoside Rk1
    CAS: 494753-69-4
    Purity: >98.00%