Thalidomide -5-methyl is the Thalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide -5-methyl can be used to synthesize PROTAC [1].
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References:
[1]. George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References:
[1]. George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.