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Dehydrogenase

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Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Products Related to Dehydrogenase(36)

  • GC10438 structure
    GC10438WIN 18446
    CAS: 1477-57-2
    Purity: >97.00%

    WIN 18446 (Fertilysin) is a potent inhibitor of aldehyde dehydrogenase 1A2 (ALDH1A2) enzyme with an IC 50 value of 0.3μM.

  • GC10462 structure
    GC104626-Aminonicotinamide
    CAS: 329-89-5
    Purity: >99.50%

    6-Aminonicotinamide is a potent nicotinamide antimetabolite and a competitive inhibitor of the NADP⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) (K i =0.46μM).

  • GC10531 structure
    GC10531AGI-5198
    CAS: 1355326-35-0
    Purity: >98.00%

    A potent, selective inhibitor of IDH1 mutations

  • GC10902 structure
    GC10902CVT 10216
    CAS: 1005334-57-5
    Purity: >99.00%

    CVT 10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), with IC 50 values of 29nM and 1.3μM for ALDH-2 and ALDH-1, respectively.

  • GC11149 structure
    GC11149L-a-Hydroxyglutaric acid disodium salt
    CAS: 63512-50-5
    Purity: >98%

    L-a-Hydroxyglutaric acid disodium salt is an epigenetic modifier and putative oncometabolite in renal cancer. L-a-Hydroxyglutaric acid disodium salt can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

  • GC12204 structure
    GC12204STK393606
    CAS: 355827-05-3
    Purity: >98%

    competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH

  • GC13147 structure
    GC13147AG-221 (Enasidenib)
    CAS: 1446502-11-9
    Purity: >99.50%

    AG-221 (Enasidenib) is an orally available, selective, and potent inhibitor of the mutant IDH2 enzyme, with an IC 50 value of 0.1μM and 0.4μM for IDH2 R140Q homodimer and IDH2 R172K homodimer, respectively.

  • GC13336 structure
    GC13336CBR-5884
    CAS: 681159-27-3
    Purity: >99.00%

    CBR-5884 is an orally active inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC 50 of 33μM.

  • GC13464 structure
    GC13464GSK 2837808A
    CAS: 1445879-21-9
    Purity: >99.00%

    GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC 50 of 2.6 nM and 43 nM for hLDHA and hLDHB.

  • GC13611 structure
    GC13611CGP 3466B maleate
    CAS: 200189-97-5
    Purity: >98.00%

    CGP 3466B maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.

  • GC13614 structure
    GC13614Mycophenolate Mofetil
    CAS: 128794-94-5
    Purity: >99.50%

    A prodrug form of mycophenolic acid

  • GC13670 structure
    GC13670Methylmalonate
    CAS: 516-05-2
    Purity: >98.00%

    Methylmalonate (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

  • GC13760 structure
    GC13760TC HSD 21
    CAS: 330203-01-5
    Purity: >98%

    17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor

  • GC13776 structure
    GC13776Piericidin A
    CAS: 2738-64-9
    Purity: >95.00%

    Piericidin A is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor.

  • GC14757 structure
    GC14757AGI-6780
    CAS: 1432660-47-3
    Purity: >98.00%

    AGI-6780 is an orally active, potent and selective mutant isocitrate dehydrogenase 2 (IDH2 R140Q ) inhibitor (IC₅₀=23±1.7nM).

  • GC14783 structure
    GC14783Trilostane
    CAS: 13647-35-3
    Purity: >99.50%

    A 3β-hydroxysteroid dehydrogenase inhibitor

  • GC14851 structure
    GC14851Vidofludimus
    CAS: 717824-30-1
    Purity: >98.50%

    DHODH inhibitor

  • GC14921 structure
    GC14921CPI-613 (Devimistat)
    CAS: 95809-78-2
    Purity: >98.00%

    An inhibitor of α-ketoglutarate dehydrogenase

  • GC15266 structure
    GC15266Qc 1
    CAS: 403718-45-6
    Purity: >98.00%

    threonine dehydrogenase (TDH) inhibitor

  • GC15547 structure
    GC15547Inosine-5'-monophosphate (sodium salt hydrate)
    CAS: 20813-76-7
    Purity: >98%

    substrate of IMP dehydrogenase (IMPDH)

  • GC15601 structure
    GC15601AG-120
    CAS: 1448347-49-6
    Purity: >98.00%

    AG-120 (Ivosidenib) is an inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1).

  • GC15738 structure
    GC15738BVT 2733
    CAS: 376640-41-4
    Purity: >98.00%

    BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor with an IC 50 value of 96nM.

  • GC15943 structure
    GC15943NCT-503
    CAS: 1916571-90-8
    Purity: >98.00%

    NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC 50 =2.5μM).

  • GC16597 structure
    GC16597Alda 1
    CAS: 349438-38-6
    Purity: >99.50%

    Alda 1 is an aldehyde dehydrogenase 2 (ALDH2) activator.