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DSP-4 (Synonyms: Neurotoxin DSP 4 hydrochloride)

Catalog No.GC12042

DSP-4 is a highly and selective adrenergic neurotoxin.

Products are for research use only. Not for human use. We do not sell to patients.

DSP-4 Chemical Structure

Cas No.: 40616-75-9

Size Price Stock Qty
1mg
$29.00
In stock
5mg
$43.00
In stock
10mg
$71.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC)[1][2].

References:
[1]. Hormigo S, et al. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Front Neural Circuits. 2012 Jun 28;6:41.
[2]. Jaim-Etcheverry G, et al. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 Apr 28;188(2):513-23.

Chemical Properties

Cas No. 40616-75-9 SDF
Synonyms Neurotoxin DSP 4 hydrochloride
Chemical Name N-(2-bromobenzyl)-2-chloro-N-ethylethanamine hydrochloride
Canonical SMILES BrC1=CC=CC=C1CN(CC)CCCl.Cl
Formula C11H15BrClN.HCl M.Wt 313.06
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml Storage Desiccate at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1943 mL 15.9714 mL 31.9428 mL
5 mM 0.6389 mL 3.1943 mL 6.3886 mL
10 mM 0.3194 mL 1.5971 mL 3.1943 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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