Home>>Signaling Pathways>> Others>> Estrogen Receptor/ERR>>α-Zearalenol

α-Zearalenol (Synonyms: β-trans-Zearalenol, (-)-β-Zearalenol)

Catalog No.GC11734

estrogen receptor agonist

Products are for research use only. Not for human use. We do not sell to patients.

α-Zearalenol Chemical Structure

Cas No.: 36455-72-8

Size Price Stock Qty
10mM (in 1mL DMSO)
$277.00
In stock
1mg
$96.00
In stock
5mg
$252.00
In stock
10mg
$378.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Zearalenone (ZEA) is a mycotoxin produced mainly by fungi in foods and feeds. It is frequently involved in reproductive disorders of farm animals and occasionally in hyperoestrogenic syndromes in humans. ZEA and its metabolites possess oestrogenic activity in cattle, pigs and sheep. However, oral or interperitoneal administration of ZEA is relatively low acute toxic in mice, rat and pig. ZEA transformed into two metabolites α-zearalenol (α-ZEA) and β-zearalenol (β-ZEA) in animals which are subsequently conjugated with glucuronic acid. Moreover, ZEA has also been shown to be hepatotoxic, haematotoxic, immunotoxic and genotoxic. α-Zearalenol is a major hepatic metabolite in rats of zearalenone which impacts mammalian reproduction and development [1].

In vitro: The binding characteristic of α-ZEA was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-ZEA inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].

References:
[1].  Zinedine A, Soriano J M, Molto J C, et al. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[J]. Food and chemical toxicology, 2007, 45(1): 1-18.
[2].  Kiang D T, Kennedy B J, Pathre S V, et al. Binding characteristics of zearalenone analogs to estrogen receptors[J]. Cancer research, 1978, 38(11 Part 1): 3611-3615.
[3].  Mirocha C J, Pathre S V, Behrens J, et al. Uterotropic activity of cis and trans isomers of zearalenone and zearalenol[J]. Applied and environmental microbiology, 1978, 35(5): 986-987.
[4].  Filannino A, Stout T A E, Gadella B M, et al. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[J]. Reproductive Biology and Endocrinology, 2011, 9(1): 134.

Chemical Properties

Cas No. 36455-72-8 SDF
Synonyms β-trans-Zearalenol, (-)-β-Zearalenol
Chemical Name (3S,7R,11E)-3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one
Canonical SMILES OC1=C(C(O[C@@H](C)CCC[C@H](O)CCC/C=C/2)=O)C2=CC(O)=C1
Formula C18H24O5 M.Wt 320.4
Solubility ≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.1211 mL 15.6055 mL 31.211 mL
5 mM 0.6242 mL 3.1211 mL 6.2422 mL
10 mM 0.3121 mL 1.5605 mL 3.1211 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for α-Zearalenol

Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for α-Zearalenol

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.