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Estrogen Receptor/ERR

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Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Products Related to Estrogen Receptor/ERR(175)

  • GC30650 structure
    GC30650ERB-196 (WAY-202196)
    CAS: 550997-55-2
    Purity: >98%

    ERB-196 (WAY-202196) is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

  • GC31008 structure
    GC31008Dienestrol
    CAS: 84-17-3
    Purity: >98.00%

    Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.

  • GC31565 structure
    GC31565NNC45-0781
    CAS: 207277-66-5
    Purity: >98%

    NNC45-0781 is a tissue-selective estrogen partial-agonist.

  • GC31589 structure
    GC31589MK-6913 (Tetrahydrofluoroene 52)
    CAS: 1398510-92-3
    Purity: >98%

    MK-6913 (Tetrahydrofluoroene 52) (Tetrahydrofluoroene 52) is a potent and selective estrogen receptor β agonist.

  • GC31746 structure
    GC31746Gestrinone (R 2323)
    CAS: 16320-04-0
    Purity: >99.00%

    An androgen and progesterone receptor ligand used to treat endometriosis

  • GC32406 structure
    GC32406H3B-6545
    CAS: 2052130-80-8
    Purity: >99.50%

    H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA) for the research of metastatic ER-positive, HER2-negative breast cancer.

  • GC32445 structure
    GC32445Nitromifene (CI628)
    CAS: 10448-84-7
    Purity: >98%

    Nitromifene (CI628) is an antagonist of estrogen receptor (ER).

  • GC32696 structure
    GC32696Elacestrant dihydrochloride (RAD1901 dihydrochloride)
    CAS: 1349723-93-8
    Purity: >99.50%

    Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a novel, orally bioavailable selective estrogen receptor (ER) degrader with IC 50 of 48nM and 870nM for ERα and ERβ, respectively.

  • GC32782 structure
    GC32782Brilanestrant (ARN-810)
    CAS: 1365888-06-7
    Purity: >99.50%

    Brilanestrant (ARN-810) (ARN-810; GDC-0810) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.

  • GC32920 structure
    GC32920GDC-0927 (SRN-927)
    CAS: 1642297-01-5
    Purity: >99.50%

    GDC-0927 (SRN-927) (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.

  • GC33011 structure
    GC33011BHPI
    CAS: 56632-39-4
    Purity: >98.00%

    An ERα antagonist

  • GC33025 structure
    GC33025Elacestrant (RAD1901)
    CAS: 722533-56-4
    Purity: >98%

    Elacestrant (RAD1901) (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.

  • GC33193 structure
    GC33193GDC-0927 Racemate (SRN-927 Racemate)
    CAS: 1443983-36-5
    Purity: >98%

    GDC-0927 Racemate (SRN-927 Racemate) (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases.

  • GC33262 structure
    GC33262H3B-5942
    CAS: 2052128-15-9
    Purity: >98.00%

    A selective estrogen receptor covalent antagonist

  • GC33349 structure
    GC33349E3 ligase Ligand 5
    CAS: 1264754-13-3
    Purity: >98.00%

    E3 ligase Ligand 5 is an estrogen-related receptor α (ERRα) antagonist with IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively.

  • GC33378 structure
    GC33378H3B-6545 Hydrochloride
    CAS: 2052132-51-9
    Purity: >99.00%

    H3B-6545 hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA) for the research of metastatic ER-positive, HER2-negative breast cancer.

  • GC33381 structure
    GC33381Arzoxifene hydrochloride (LY 353381 HCl)
    CAS: 182133-27-3
    Purity: >98%

    Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

  • GC33402 structure
    GC33402Idoxifene (CB7432)
    CAS: 116057-75-1
    Purity: >98%

    Idoxifene (CB7432) (CB7432) is a novel tissue-specific selective estrogen receptor modulator (SERM).

  • GC34006 structure
    GC34006Equilin (7-Dehydroestrone)
    CAS: 474-86-2
    Purity: >99.00%

    Equilin (7-Dehydroestrone) (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone).

  • GC34151 structure
    GC34151PAC
    CAS: 2158322-33-7
    Purity: >98.00%

    PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

  • GC34153 structure
    GC34153Pipendoxifene hydrochloride
    CAS: 245124-69-0
    Purity: >99.00%

    Pipendoxifene hydrochloride is a selective estrogen receptor modulator (SERM) that can be used for the research of breast cancer.

  • GC34293 structure
    GC34293Elacestrant S enantiomer (RAD1901 S enantiomer)
    Purity: >98%
  • GC34294 structure
    GC34294Elacestrant S enantiomer dihydrochloride (RAD1901 S enantiomer dihydrochloride)
    Purity: >98%
  • GC34341 structure
    GC34341PROTAC ERα Degrader-1
    CAS: 2417369-94-7
    Purity: >98%

    PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.