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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Products for  Estrogen Receptor/ERR

  1. Cat.No. Product Name Information
  2. GC11822 Erteberel (LY500307)

    ERβ agonist, potent and selective

  3. GC19478 Estetrol

    An estrogen steroid hormone

  4. GC11282 Estradiol Sex hormone
  5. GC15245 Estradiol Benzoate Estrogen/progestogen receptor agonist
  6. GC10139 Estradiol Cypionate Estrogen receptor inhibitor
  7. GC11796 Estradiol valerate Estrogen receptor agonist
  8. GC12182 Estriol Estrogen receptor antagonist
  9. GC14385 Estrone Estrogenic hormone
  10. GC16852 Estropipate Estrogen receptor agonist
  11. GC12148 Ethinyl Estradiol Oral contraceptive
  12. GC18000 Fulvestrant (ICI 182,780)

    Estrogen receptor antagonist,high affinity

  13. GC12766 G-1

    GPR30 agonist, potent and selective

  14. GC16618 G-15

    GPER receptor antagonist

  15. GC32920 GDC-0927 (SRN-927)
  16. GC33193 GDC-0927 Racemate (SRN-927 Racemate)
  17. GC31746 Gestrinone (R 2323)
  18. GC10558 GSK 4716 estrogen-related receptors ERRβ and ERRγ agonist
  19. GC36201 GW7604
  20. GN10566 Gypenoside XVII Extracted from Gynostemsma Pentaphyllum Makin;Store the product in sealed, cool and dry condition
  21. GC33262 H3B-5942

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