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Estrogen Receptor/ERR

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Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Products Related to Estrogen Receptor/ERR(175)

  • GC13350 structure
    GC13350Raloxifene HCl
    CAS: 82640-04-8
    Purity: >99.50%

    Raloxifene HCl (Keoxifene hydrochloride) is a second generationselective and orally active estrogen receptor modulator.

  • GC13477 structure
    GC13477Mestranol
    CAS: 72-33-3
    Purity: >99.50%

    Estrogen used in contraceptives

  • GC13835 structure
    GC13835Toremifene Citrate
    CAS: 89778-27-8
    Purity: >99.50%

    Oral selective estrogen receptor modulator (SERM)

  • GC13887 structure
    GC1388725(R)-27-hydroxy Cholesterol
    CAS: 20380-11-4
    Purity: >98.00%

    25(R)-27-hydroxy Cholesterol is an agonist of liver X receptor (LXR) α and LXRβ, with the EC 50 of 0.085 and 0.071μM, respectively.

  • GC14370 structure
    GC14370Propyl pyrazole triol (PPT)
    CAS: 263717-53-9
    Purity: >98.00%

    Propyl pyrazole triol (PPT) is a selective estrogen receptor α (ERα) agonist that can shield neurons from oxidative stress and inflammatory damage through ERα activation in the nervous system.

  • GC14385 structure
    GC14385Estrone
    CAS: 53-16-7
    Purity: >98.00%

    Estrone is one of the three major endogenous estrogens, the others being estradiol and estriol.

  • GC14405 structure
    GC14405AZD9496
    CAS: 1639042-08-2
    Purity: >99.00%

    estrogen receptor inhibitor, orally active

  • GC14883 structure
    GC14883Bazedoxifene
    CAS: 198481-32-2
    Purity: >98%
  • GC15245 structure
    GC15245Estradiol Benzoate
    CAS: 50-50-0
    Purity: >99.50%

    Estradiol Benzoate is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol Benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice.

  • GC15366 structure
    GC15366Clomiphene citrate
    CAS: 50-41-9
    Purity: >98.00%

    Selective estrogen receptor modulator

  • GC15730 structure
    GC15730Kaempferide
    CAS: 491-54-3
    Purity: >99.00%

    A flavonoid with diverse biological activities

  • GC16292 structure
    GC16292Equol
    CAS: 94105-90-5
    Purity: >98.00%

    non-steroidal estrogen

  • GC16618 structure
    GC16618G-15
    CAS: 1161002-05-6
    Purity: >99.00%

    G-15 is a high-affinity, selective antagonist of G protein-coupled estrogen receptor (GPER/ GPR30) (K i = 20nM).

  • GC16852 structure
    GC16852Estropipate
    CAS: 7280-37-7
    Purity: >98.00%

    Estrogen receptor agonist

  • GC17398 structure
    GC17398Cholesterol
    CAS: 57-88-5
    Purity: >99.00%

    Major sterol in mammals

  • GC17588 structure
    GC17588Bavachin
    CAS: 19879-32-4
    Purity: >98.00%

    estrogen receptors ERα and ERβ activator

  • GC17688 structure
    GC17688Diarylpropionitrile(DPN)
    CAS: 1428-67-7
    Purity: >99.50%

    Diarylpropionitrile(DPN) (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM.

  • GC17803 structure
    GC178034-Hydroxytamoxifen
    CAS: 68392-35-8
    Purity: >98.00%

    4-hydroxytamoxifen is a major metabolite of tamoxifen and selective estrogen receptor antagonist.

  • GC17901 structure
    GC17901Tamoxifen
    CAS: 10540-29-1
    Purity: >98.00%

    Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues.

  • GC18000 structure
    GC18000Fulvestrant (ICI 182,780)
    CAS: 129453-61-8
    Purity: >98.00%

    Fulvestrant is a selective estrogen receptor (ER) antagonist. It binds, blocks and degrades estrogen receptor, then inhibits estrogen receptor(ER)-mediated transcriptional activity with an IC 50 of 9.4 nM .

  • GC18362 structure
    GC18362Acolbifene
    CAS: 182167-02-8
    Purity: >98.50%

    Acolbifene is a selective estrogen receptor modulator (SERM).

  • GC19224 structure
    GC19224LSZ-102
    CAS: 2135600-76-7

    LSZ-102 is a potent, orally bioavailable selective estrogen receptor degrader with an IC50 of 0.2 nM.

  • GC19478 structure
    GC19478Estetrol
    CAS: 15183-37-6
    Purity: >98%

    An estrogen steroid hormone

  • GC19498 structure
    GC19498β-Estradiol 17-acetate
    CAS: 1743-60-8
    Purity: >99.00%

    β-Estradiol 17-acetate is a metabolite of estradiol