FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. [1] The IC50 for the inhibition of platelet aggregation is 4.9 µM. [2]
Reference:
[1]. Kita, Y., Hirasawa, Y., Maeda, K., et al. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. European Journal of Pharmacology 257, 123-130 (1994).
[2]. Fukuyama, S., Hirasawa, Y., Kato, Y., et al. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. Journal of Pharmacology and Experimental Therapeutics 282, 236-242 (1997).