Z-321 |
Catalog No.GC31152
One-Click Copy Product Info
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Z-321 is a prolylendopeptidase (PEP) inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130849-58-0
Sample solution is provided at 25 µL, 10mM.
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Z-321 is a prolylendopeptidase (PEP) inhibitor.
Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity[1].
[1]. Oosuka I, et al. Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. Jpn J Pharmacol. 2000 May;83(1):82-5.
Animal experiment: | Femal wistar rats (200 to 250 g) are used and housed under conditions of controlled temperature (23 to 26°C) and photoperiod (14: 10 h, light:dark). Fifty four rats are ovariectomized under ether anesthesia. Two weeks after ovariectomy, sexual behavioral tests are carried out before and after a treatment with Z-321 (100, 200 or 300 mg/kg). Another group of rats, 7 females are given 1 mL/kg of 10% gum arabic as control group[1]. |
References: [1]. Oosuka I, et al. Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. Jpn J Pharmacol. 2000 May;83(1):82-5. | |
| Cas No. | 130849-58-0 | SDF | |
| Canonical SMILES | O=C([C@H]1N(C(CC2CC3=C(C=CC=C3)C2)=O)CSC1)N4CCCC4 | ||
| Formula | C19H24N2O2S | M.Wt | 344.47 |
| Solubility | DMSO: 250 mg/mL (725.75 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.903 mL | 14.5151 mL | 29.0301 mL |
| 5 mM | 580.6 μL | 2.903 mL | 5.806 mL |
| 10 mM | 290.3 μL | 1.4515 mL | 2.903 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)