5-Androstenetriol is a steroid and an active metabolite of dehydroepiandrosterone .1 In vivo, 5-androstenetriol (0.75 mg/25 g body weight) reduces radiation-induced lethality and induces hematopoietic recovery from surviving stem cells in mice. It increases survival in a rat model of surgical trauma-induced sepsis when administered at a dose of 40 mg/kg.2 Urinary levels of 5-androstenetriol are increased in women with androgenic alopecia.3
1.Loria, R.M., Conrad, D.H., Huff, T., et al.Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injuryAnn. N. Y. Acad. Sci.917(1)860-867(2000) 2.Marcu, A.C., Kielar, N.D., Paccione, K.E., et al.Androstenetriol improves survival in a rodent model of traumatic shockResuscitation71(3)379-386(2006) 3.Juricskay, S., and Telegdy, E.Urinary steroids in women with androgenic alopeciaClin. Biochem.33(2)97-101(2000)