Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Research Areas
- ATM/ATR(28)
- Aurora Kinase(35)
- Cdc42(4)
- Cdc7(3)
- Chk(13)
- c-Myc(51)
- CRM1(10)
- Cyclin-Dependent Kinases(70)
- E1 enzyme(1)
- G-quadruplex(16)
- Haspin(6)
- HMTase(1)
- Kinesin(32)
- Ksp(4)
- Microtubule/Tubulin(300)
- Mps1(17)
- Mitotic(7)
- RAD51(13)
- ROCK(76)
- Rho(13)
- PERK(21)
- PLK(51)
- PTEN(7)
- Wee1(15)
- PAK(29)
- Arp2/3 Complex(10)
- Dynamin(18)
- ECM & Adhesion Molecules(53)
- Cholesterol Metabolism(10)
- Endomembrane System & Vesicular Trafficking(34)
- G1(50)
- G2/M(35)
- G2/S(16)
- Genotoxic Stress(22)
- Inositol Phosphates(65)
- Proteolysis(179)
- Cytoskeleton & Motor Proteins(71)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(2)
- MARK(4)
- NEKs(9)
- ATF6(2)
- ClpP(6)
- Disulfidptosis(1)
- HMG Family(1)
- PDI(1)
- SWI/SNF Complex(7)
- VISTA(4)
- HOXA(1)
Products Related to Cell Cycle/Checkpoint(1536)
- GC81597Momilactone BCAS: 51415-08-8Purity: >99.00%
Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC 50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC 50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase.
- GC81614ZotadirsenPurity: >98.00%
Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker.
- GC81619(S)-BleximenibCAS: 2654081-27-1Purity: >96.00%
(S)-Bleximenib (Compound 28) ((S)-JNJ-75276617) is an isoform of Bleximenib.
- GC81621Mertansine- 13 C,d 3Purity: >98.00%
Mertansine - 13 C,d 3 (DM1- 13 C,d 3 ) is the 13 C- and deuterium labeled Mertansine.
- GC81675MKI-2 hydrochloridePurity: >99.50%
MKI-2 hydrochloride is a selective MASTL inhibitor with an IC 50 of 37.44 nM.
- GC81777ABS-752 hydrochlorideCAS: 2922884-90-8Purity: >98.50%
ABS-752 hydrochloride is an orally active prodrug targeting CRBN-modulating molecular glue with selectivity in protein degradation.
- GC81880OSU-2S TFAPurity: >98.00%
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).
- GC90366Dolastatin 15 (trifluoroacetate salt)Purity: >98.00%
Un peptide avec une activité anticancéreuse
- GC90538Mca-RPPGFSAFK(Dnp)-OH (trifluoroacetate salt)Purity: >95.00%
Un substrat fluorogène pour ECE-1
- GC90554E70K (trifluoroacetate salt)Purity: >98.00%
Un inhibiteur peptidique de l'interaction CXCL8-GAG
- GC90559Mca-KPLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)CAS: 1392300-20-7Purity: >95.00%
Un substrat fluorogène pour les MMPs
- GC90622Carbaethopendecine (bromide)CAS: 10567-02-9Purity: >95.00%
Un tensioactif cationique contenant de l'ammonium quaternaire avec une activité antibiotique.
- GC90682Methyl Parathion-d6CAS: 96740-32-8Purity: >99.00%
Un standard interne pour la quantification du méthyl parathion.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC81554 | CP05 | 1824650-30-7 | >97.00% | |
CP05 is a peptide that specifically recognizes an exosome surface marker ( CD63 ). | ||||
| GC81555 | GPLGVRGC | 1257658-47-1 | >98.00% | |
GPLGVRG C is a cysteine-tagged variant of GPLGVRG. | ||||
| GC81597 | Momilactone B | 51415-08-8 | >99.00% | |
Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC 50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC 50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase. | ||||
| GC81614 | Zotadirsen | - | >98.00% | |
Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker. | ||||
| GC81619 | (S)-Bleximenib | 2654081-27-1 | >96.00% | |
(S)-Bleximenib (Compound 28) ((S)-JNJ-75276617) is an isoform of Bleximenib. | ||||
| GC81620 | Auristatin E-d 8 | - | >99.00% | |
Auristatin E-d 8 is the deuterium labeled Auristatin E. | ||||
| GC81621 | Mertansine- 13 C,d 3 | - | >98.00% | |
Mertansine - 13 C,d 3 (DM1- 13 C,d 3 ) is the 13 C- and deuterium labeled Mertansine. | ||||
| GC81674 | MKI-3 | 3084702-28-0 | >98.00% | |
MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM. | ||||
| GC81675 | MKI-2 hydrochloride | - | >99.50% | |
MKI-2 hydrochloride is a selective MASTL inhibitor with an IC 50 of 37.44 nM. | ||||
| GC81684 | CK37 | 1001478-90-5 | >98.00% | |
CK37 is a competitive choline kinase-α inhibitor. | ||||
| GC81777 | ABS-752 hydrochloride | 2922884-90-8 | >98.50% | |
ABS-752 hydrochloride is an orally active prodrug targeting CRBN-modulating molecular glue with selectivity in protein degradation. | ||||
| GC81879 | NCP26 TFA | - | >99.50% | |
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline). | ||||
| GC81880 | OSU-2S TFA | - | >98.00% | |
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720). | ||||
| GC90366 | Dolastatin 15 (trifluoroacetate salt) | - | >98.00% | |
Un peptide avec une activité anticancéreuse | ||||
| GC90538 | Mca-RPPGFSAFK(Dnp)-OH (trifluoroacetate salt) | - | >95.00% | |
Un substrat fluorogène pour ECE-1 | ||||
| GC90554 | E70K (trifluoroacetate salt) | - | >98.00% | |
Un inhibiteur peptidique de l'interaction CXCL8-GAG | ||||
| GC90559 | Mca-KPLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt) | 1392300-20-7 | >95.00% | |
Un substrat fluorogène pour les MMPs | ||||
| GC90582 | Perfluorooctanesulfonic Acid | 1763-23-1 | >98.00% | |
Une substance perfluoroalkyle | ||||
| GC90611 | RTDLDSLRTYTL (trifluoroacetate salt) | - | >98.00% | |
Un ligand de l'intégrine αVβ6. | ||||
| GC90622 | Carbaethopendecine (bromide) | 10567-02-9 | >95.00% | |
Un tensioactif cationique contenant de l'ammonium quaternaire avec une activité antibiotique. | ||||
| GC90653 | ERX-41 | 2440087-54-5 | >98.00% | |
Un inducteur de stress ER (réticulum endoplasmique). | ||||
| GC90664 | Fluostatin B | 158906-40-2 | >90.00% | |
Un inhibiteur de la fluorénone et de DPP-3 | ||||
| GC90669 | Negamycin (hydrochloride) | - | >80.00% | |
Un antibiotique | ||||
| GC90682 | Methyl Parathion-d6 | 96740-32-8 | >99.00% | |
Un standard interne pour la quantification du méthyl parathion. | ||||