THZ1-R |
| Catalog No.GC37786 |
A non-cysteine reactive derivative of THZ1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1621523-07-6
Sample solution is provided at 25 µL, 10mM.
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THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. CDK7|146 nM (IC50)
THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1].
[1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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