GLPBio

TM6089

Catalog No.: GC37801Purity:>98%
COASDSData Sheet
TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia.

Products are for research use only. Not for human use. We do not sell to patients.

TM6089
Cas No.: 863421-32-3
10mM (in 1mL DMSO)In Stock
$146.00
1
1mgIn Stock
$86.00
1
5mgIn Stock
$217.00
1
10mgIn Stock
$294.00
1
25mgIn Stock
$469.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector[1].

[1]. Nangaku M, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54.

Chemical Properties

CAS No.
863421-32-3
SMILES
O=C1N(C(C(C(CSC2=NC=CC=C2)=O)=C(N1C)N)=O)C
Molecular Formula
C13H14N4O3S
Molecular Weight
306.34
Solubility
DMSO : 41.67 mg/mL (136.03 mM; ultrasonic and warming and heat to 60°C)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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