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HIF

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Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

Products Related to HIF(118)

  • GC12698 structure
    GC12698BAY 87-2243
    CAS: 1227158-85-1
    Purity: >99.50%

    BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).

  • GC10046 structure
    GC10046Molidustat (BAY85-3934)
    CAS: 1154028-82-6
    Purity: >99.00%

    Molidustat (BAY85-3934) (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3.

  • GC11031 structure
    GC11031PX-478 2HCl
    CAS: 685898-44-6
    Purity: >98.00%

    PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.

  • GC11767 structure
    GC11767Hydralazine HCl
    CAS: 304-20-1
    Purity: >99.50%

    Hydralazine HCl is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel.

  • GC12255 structure
    GC12255IOX4
    CAS: 1154097-71-8
    Purity: >99.50%

    PHD2 inhibitor

  • GC12487 structure
    GC12487Adaptaquin
    CAS: 385786-48-1
    Purity: >98%

    HIF-prolyl hydroxylase-2 (PHD2) inhibitor

  • GC12821 structure
    GC12821Oltipraz
    CAS: 64224-21-1
    Purity: >99.50%

    Oltipraz is an HIF-1α inhibitor (IC 50 =10μM) and an Nrf2 activator.

  • GC13018 structure
    GC13018IOX2(Glycine)
    CAS: 931398-72-0
    Purity: >99.50%

    A selective PHD2 inhibitor

  • GC13139 structure
    GC13139FG-4592 (ASP1517)
    CAS: 808118-40-3
    Purity: >99.50%

    FG-4592 (ASP1517) is an oral bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stimulates erythropoiesis.

  • GC13141 structure
    GC13141KC7F2
    CAS: 927822-86-4
    Purity: >98.00%

    KC7F2 is an inhibitor of the transcription factor HIF-1 (hypoxia-inducible factor-1), with an IC₅₀ of 20μM, KC7F2 is commonly used in research on tumor development and angiogenesis.

  • GC14282 structure
    GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)
    CAS: 67416-61-9
    Purity: >98.00%

    AKBA (3-acetyl-11-keto-β-Boswellic Acid) is a pentacyclic triterpene acid that effectively and non-competitively inhibits 5-lipoxygenase (5-LOX), exhibiting various biological activities including anti-inflammatory, antitumor, and neuroprotective effects.

  • GC14319 structure
    GC14319ML 228
    CAS: 1357171-62-0
    Purity: >98.00%

    A HIF pathway activator

  • GC15084 structure
    GC150842-Methoxyestradiol (2-MeOE2)
    CAS: 362-07-2
    Purity: >98.00%

    2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor.

  • GC15379 structure
    GC15379JNJ-42041935
    CAS: 1193383-09-3
    Purity: >99.50%

    Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor

  • GC15473 structure
    GC15473Amifostine
    CAS: 20537-88-6
    Purity: >98.00%

    Amifostine, an inorganic thiophosphate, is a selective broad-spectrum cytoprotector of normal tissues.

  • GC15594 structure
    GC15594PX 12
    CAS: 141400-58-0
    Purity: >98.00%

    An irreversible inhibitor of thioredoxin-1

  • GC16195 structure
    GC161952,4-DPD
    CAS: 41438-38-4
    Purity: >98%

    Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor.

  • GC16638 structure
    GC16638FG2216
    CAS: 223387-75-5
    Purity: >99.00%

    HIF-prolyl hydroxylase inhibitor

  • GC16647 structure
    GC16647Daprodustat(GSK1278863)
    CAS: 960539-70-2
    Purity: >98.00%

    Daprodustat(GSK1278863) (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

  • GC16811 structure
    GC16811Vadadustat
    CAS: 1000025-07-9
    Purity: >98.00%

    HIF-PH inhibitor

  • GC17358 structure
    GC17358Octyl-α-ketoglutarate
    CAS: 876150-14-0
    Purity: >95.00%

    prolyl hydroxylases (PHD) activator

  • GC17405 structure
    GC17405Chetomin
    CAS: 1403-36-7
    Purity: >95.00%

    Chetomin is a natural alkaloid derived from Chaetomium species, known for its significant anticancer and anti-inflammatory properties.

  • GC18236 structure
    GC18236Echinomycin
    CAS: 512-64-1
    Purity: >95.00%

    An inhibitor of HIF1mediated gene transcription

  • GC19251 structure
    GC19251MK-8617
    CAS: 1187990-87-9
    Purity: >98.00%

    MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.